Idioma:

Blood pressure variability and outcome in acute ischemic and hemorrhagic stroke: a post hoc analysis of the HeadPoST study

Minhas, Jatinder S ; Wang, Xia ; Lavados, Pablo M ; Moullaali, Tom J ; Arima, Hisatomi ; Billot, Laurent ; Hackett, Maree L ; Olavarria, Veronica V ; Middleton, Sandy ; Pontes-Neto, Octavio ; De Silva, H Asita ; Lee, Tsong-Hai ; Pandian, Jeyaraj D ; Mead, Gillian E ; Watkins, Caroline ; Chalmers, John ; Anderson, Craig S ; Robinson, Thompson G

Journal of human hypertension, 2019-05, Vol.33 (5), p.411-418 [Periódico revisado por pares]

England: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Blood pressure variability and outcome in acute ischemic and hemorrhagic stroke: a post hoc analysis of the HeadPoST study
Autor: Minhas, Jatinder S ; Wang, Xia ; Lavados, Pablo M ; Moullaali, Tom J ; Arima, Hisatomi ; Billot, Laurent ; Hackett, Maree L ; Olavarria, Veronica V ; Middleton, Sandy ; Pontes-Neto, Octavio ; De Silva, H Asita ; Lee, Tsong-Hai ; Pandian, Jeyaraj D ; Mead, Gillian E ; Watkins, Caroline ; Chalmers, John ; Anderson, Craig S ; Robinson, Thompson G
Assuntos: Aged ; Aged, 80 and over ; Blood Pressure ; Brain Ischemia - diagnosis ; Brain Ischemia - physiopathology ; Brain Ischemia - therapy ; Cross-Over Studies ; Disability Evaluation ; Female ; Health aspects ; Hemorrhage ; Humans ; Intracranial Hemorrhages - diagnosis ; Intracranial Hemorrhages - physiopathology ; Intracranial Hemorrhages - therapy ; Ischemia ; Male ; Middle Aged ; Patient outcomes ; Patient Positioning ; Patients ; Positioning ; Prognosis ; Regression analysis ; Risk Factors ; Sitting Position ; Stroke ; Stroke (Disease) ; Stroke - diagnosis ; Stroke - physiopathology ; Stroke - therapy ; Supine Position ; Time Factors
É parte de: Journal of human hypertension, 2019-05, Vol.33 (5), p.411-418
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Undefined-2
Joint First Authors
Descrição: The Head Positioning in Acute Stroke Trial (HeadPoST) is a pragmatic, international, cluster crossover randomized trial of 11,093 patients with acute stroke assigned to a lying-flat (0°) or sitting-up (head elevated ≥30°) position. This post hoc analysis aimed to determine the association between blood pressure variability (BPV) and outcomes for patients from a wide range of international clinical settings and how the association was modified by randomized head position. BPV was defined according to the standard criteria, with the key parameter considered the coefficient of variation (CV) of systolic BP (SBP) over 24 h. Outcome was ordinal 90-day Modified Rankin Scale (mRS) score. The association was analyzed by ordinal, logistic regression, hierarchical, mixed models with fixed intervention (lying flat vs. sitting up), and fixed period, random cluster, and random cluster-period, effects. Nine thousand one hundred and fifty six (8324 acute ischemic stroke and 817 intracerebral hemorrhage; mean age 68.1 years; 39.2% women) were included in the analysis. CV of SBP had a significant linear association with unfavorable shift of mRS at 90 days (adjusted odds ratio 1.06, 95% confidence interval 1.02-1.11; P = 0.01). There was no heterogeneity of the association by randomized head positioning. In addition, CV of diastolic BP (DBP) (1.08, 1.03-1.12; P = 0.001) over 24 h post stroke was significantly associated with 3-month poor outcome. The association was more apparent in sitting-up position (1.12, 1.06-1.19) compared with lying-flat position (1.03, 0.98-1.09) (P interaction = 0.005). BPV was associated with adverse stroke outcome, and the magnitude of the association was greater with sitting-up head positioning in terms of DBP variability.
Editor: England: Nature Publishing Group
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Blood pressure variability and outcome in acute ischemic and hemorrhagic stroke: a post hoc analysis of the HeadPoST study

England: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.