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Different pain, different brain: thalamic anatomy in neuropathic and non-neuropathic chronic pain syndromes

Gustin, Sylvia M ; Peck, Chris C ; Wilcox, Sophie L ; Nash, Paul G ; Murray, Greg M ; Henderson, Luke A

The Journal of neuroscience, 2011-04, Vol.31 (16), p.5956-5964 [Periódico revisado por pares]

United States: Society for Neuroscience

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Título:
Different pain, different brain: thalamic anatomy in neuropathic and non-neuropathic chronic pain syndromes
Autor: Gustin, Sylvia M ; Peck, Chris C ; Wilcox, Sophie L ; Nash, Paul G ; Murray, Greg M ; Henderson, Luke A
Assuntos: Adult ; Aged ; Brain Mapping ; Chronic Disease ; Female ; Humans ; Life sciences ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Nerve Fibers, Unmyelinated - pathology ; Neuralgia - pathology ; Neuralgia - physiopathology ; Neuralgia/pathology/physiopathology ; Organ Size ; Sciences du vivant ; Temporomandibular Joint Disorders - pathology ; Temporomandibular Joint Disorders - physiopathology ; Temporomandibular Joint Disorders/pathology/physiopathology ; Thalamus - pathology ; Thalamus - physiopathology ; Thalamus/pathology/physiopathology
É parte de: The Journal of neuroscience, 2011-04, Vol.31 (16), p.5956-5964
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
scopus-id:2-s2.0-79955757713
Author contributions: S.M.G., C.C.P., G.M.M., and L.A.H. designed research; S.M.G., C.C.P., S.W., P.G.N., G.M.M., and L.A.H. performed research; S.M.G., S.W., P.G.N., and L.A.H. analyzed data; S.M.G., C.C.P., S.W., G.M.M., and L.A.H. wrote the paper.
Descrição: Trigeminal neuropathic pain (TNP) and temporomandibular disorders (TMD) are thought to have fundamentally different etiologies. It has been proposed that TNP arises through damage to, or pressure on, somatosensory afferents in the trigeminal nerve, whereas TMD results primarily from peripheral nociceptor activation. Because some reports suggest that neuropathic pain is associated with changes in brain anatomy, it is possible that TNP is maintained by changes in higher brain structures, whereas TMD is not. The aim of this investigation is to determine whether changes in regional brain anatomy and biochemistry occur in both conditions. Twenty-one TNP subjects, 20 TMD subjects, and 36 healthy controls were recruited. Voxel-based morphometry of T1-weighted anatomical images revealed no significant regional gray matter volume change in TMD patients. In contrast, gray matter volume of TNP patients was reduced in the primary somatosensory cortex, anterior insula, putamen, nucleus accumbens, and the thalamus, whereas gray matter volume was increased in the posterior insula. The thalamic volume decrease was only seen in the TNP patients classified as having trigeminal neuropathy but not those with trigeminal neuralgia. Furthermore, in trigeminal neuropathy patients, magnetic resonance spectroscopy revealed a significant reduction in the N-acetylaspartate/creatine ratio, a biochemical marker of neural viability, in the region of thalamic volume loss. The data suggest that the pathogenesis underlying neuropathic and non-neuropathic pain conditions are fundamentally different and that neuropathic pain conditions that result from peripheral injuries may be generated and/or maintained by structural changes in regions such as the thalamus.
Editor: United States: Society for Neuroscience
Idioma: Inglês

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Different pain, different brain: thalamic anatomy in neuropathic and non-neuropathic chronic pain syndromes

Gustin, Sylvia M ; Peck, Chris C ; Wilcox, Sophie L ; Nash, Paul G ; Murray, Greg M ; Henderson, Luke A

United States: Society for Neuroscience

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