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In order for the light to shine so brightly, the darkness must be present-why do cancers fluoresce with 5-aminolaevulinic acid?

McNicholas, Kym ; MacGregor, Melanie N ; Gleadle, Jonathan M

British journal of cancer, 2019-10, Vol.121 (8), p.631-639 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
In order for the light to shine so brightly, the darkness must be present-why do cancers fluoresce with 5-aminolaevulinic acid?
Autor: McNicholas, Kym ; MacGregor, Melanie N ; Gleadle, Jonathan M
Assuntos: Amino Acid Transport Systems - metabolism ; Aminolevulinic Acid ; Bladder cancer ; Brain Neoplasms - diagnostic imaging ; Brain Neoplasms - drug therapy ; Brain Neoplasms - metabolism ; Brain tumors ; Cancer ; Coproporphyrinogens - metabolism ; Darkness ; Ferrochelatase - metabolism ; Fluorescence ; Glucose - metabolism ; Haem ; Heme - biosynthesis ; Humans ; Hypoxia ; Iron - metabolism ; MicroRNAs - metabolism ; Mitochondria - metabolism ; Mutation ; NADP - metabolism ; Neoplasms - diagnostic imaging ; Neoplasms - drug therapy ; Neoplasms - metabolism ; Oncogenes - genetics ; Oncology ; Optical Imaging ; Peptide Transporter 1 - metabolism ; Photochemotherapy ; Protoporphyrin ; Protoporphyrin IX ; Protoporphyrins - metabolism ; Review ; Skin Neoplasms - diagnostic imaging ; Skin Neoplasms - drug therapy ; Skin Neoplasms - metabolism ; Symporters - metabolism ; Tumor Hypoxia ; Tumor Microenvironment ; Tumors ; Urinary Bladder Neoplasms - diagnostic imaging ; Urinary Bladder Neoplasms - drug therapy ; Urinary Bladder Neoplasms - metabolism
É parte de: British journal of cancer, 2019-10, Vol.121 (8), p.631-639
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Photodynamic diagnosis and therapy have emerged as a promising tool in oncology. Using the visible fluorescence from photosensitisers excited by light, clinicians can both identify and treat tumour cells in situ. Protoporphyrin IX, produced in the penultimate step of the haem synthesis pathway, is a naturally occurring photosensitiser that visibly fluoresces when exposed to light. This fluorescence is enhanced considerably by the exogenous administration of the substrate 5-aminolaevulinic acid (5-ALA). Significantly, 5-ALA-induced protoporphyrin IX accumulates preferentially in cancer cells, and this enhanced fluorescence has been harnessed for the detection and photodynamic treatment of brain, skin and bladder tumours. However, surprisingly little is known about the mechanistic basis for this phenomenon. This review focuses on alterations in the haem pathway in cancer and considers the unique features of the cancer environment, such as altered glucose metabolism, oncogenic mutations and hypoxia, and their potential effects on the protoporphyrin IX phenomenon. A better understanding of why cancer cells fluoresce with 5-ALA would improve its use in cancer diagnostics and therapies.
Editor: England: Nature Publishing Group
Idioma: Inglês

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In order for the light to shine so brightly, the darkness must be present-why do cancers fluoresce with 5-aminolaevulinic acid?

McNicholas, Kym ; MacGregor, Melanie N ; Gleadle, Jonathan M

England: Nature Publishing Group

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