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Pathogenic Puppetry: Manipulation of the Host Actin Cytoskeleton by Chlamydia trachomatis

Caven, Liam ; Carabeo, Rey A

International journal of molecular sciences, 2019-12, Vol.21 (1), p.90 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Pathogenic Puppetry: Manipulation of the Host Actin Cytoskeleton by Chlamydia trachomatis
Autor: Caven, Liam ; Carabeo, Rey A
Assuntos: Actin ; Actin Cytoskeleton - metabolism ; Adhesins ; Animals ; Cellular structure ; Chlamydia ; Chlamydia Infections - metabolism ; Chlamydia Infections - microbiology ; Chlamydia trachomatis ; Chlamydia trachomatis - metabolism ; Chlamydia trachomatis - pathogenicity ; Crosslinking ; Cytoskeleton ; E coli ; Egress ; Endocytosis ; Epithelium ; Extrusion ; Heparan sulfate ; Host-Pathogen Interactions ; Humans ; Kinases ; Listeria ; Myosin ; Pathogenesis ; Pathogens ; Phagocytes ; Polymerization ; Proteins ; Review ; Salmonella
É parte de: International journal of molecular sciences, 2019-12, Vol.21 (1), p.90
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: The actin cytoskeleton is crucially important to maintenance of the cellular structure, cell motility, and endocytosis. Accordingly, bacterial pathogens often co-opt the actin-restructuring machinery of host cells to access or create a favorable environment for their own replication. The obligate intracellular organism and related species exemplify this dynamic: by inducing actin polymerization at the site of pathogen-host attachment, induce their own uptake by the typically non-phagocytic epithelium they infect. The interaction of chlamydial adhesins with host surface receptors has been implicated in this effect, as has the activity of the chlamydial effector TarP (translocated actin recruitment protein). Following invasion, dynamically assembles and maintains an actin-rich cage around the pathogen's membrane-bound replicative niche, known as the chlamydial inclusion. Through further induction of actin polymerization and modulation of the actin-crosslinking protein myosin II, promotes egress from the host via extrusion of the inclusion. In this review, we present the experimental findings that can inform our understanding of actin-dependent chlamydial pathogenesis, discuss lingering questions, and identify potential avenues of future study.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Pathogenic Puppetry: Manipulation of the Host Actin Cytoskeleton by Chlamydia trachomatis

Caven, Liam ; Carabeo, Rey A

Switzerland: MDPI AG

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