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Comparison of Hospitalized Patients With ARDS Caused by COVID-19 and H1N1

Tang, Xiao ; Du, Rong-Hui ; Wang, Rui ; Cao, Tan-Ze ; Guan, Lu-Lu ; Yang, Cheng-Qing ; Zhu, Qi ; Hu, Ming ; Li, Xu-Yan ; Li, Ying ; Liang, Li-Rong ; Tong, Zhao-Hui ; Sun, Bing ; Peng, Peng ; Shi, Huan-Zhong

Chest, 2020-07, Vol.158 (1), p.195-205 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Comparison of Hospitalized Patients With ARDS Caused by COVID-19 and H1N1
Autor: Tang, Xiao ; Du, Rong-Hui ; Wang, Rui ; Cao, Tan-Ze ; Guan, Lu-Lu ; Yang, Cheng-Qing ; Zhu, Qi ; Hu, Ming ; Li, Xu-Yan ; Li, Ying ; Liang, Li-Rong ; Tong, Zhao-Hui ; Sun, Bing ; Peng, Peng ; Shi, Huan-Zhong
Assuntos: Age Factors ; Antiviral Agents - therapeutic use ; ARDS ; Betacoronavirus - isolation & purification ; Case-Control Studies ; China - epidemiology ; Coronavirus Infections - diagnosis ; Coronavirus Infections - mortality ; Coronavirus Infections - physiopathology ; COVID-19 ; Diagnosis, Differential ; Female ; H1N1 ; Hospital Mortality ; Humans ; influenza A ; Influenza A Virus, H1N1 Subtype - isolation & purification ; Influenza, Human - diagnosis ; Influenza, Human - mortality ; Influenza, Human - physiopathology ; Male ; Middle Aged ; mortality ; Organ Dysfunction Scores ; Pandemics ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - mortality ; Pneumonia, Viral - physiopathology ; Prognosis ; SARS-CoV-2 ; Severity of Illness Index ; Sex Factors ; Symptom Assessment - methods ; Symptom Assessment - statistics & numerical data
É parte de: Chest, 2020-07, Vol.158 (1), p.195-205
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: Since the outbreak of coronavirus disease 2019 (COVID-19) in China in December 2019, considerable attention has been focused on its elucidation. However, it is also important for clinicians and epidemiologists to differentiate COVID-19 from other respiratory infectious diseases such as influenza viruses. The aim of this study was to explore the different clinical presentations between COVID-19 and influenza A (H1N1) pneumonia in patients with ARDS. This analysis was a retrospective case-control study. Two independent cohorts of patients with ARDS infected with either COVID-19 (n = 73) or H1N1 (n = 75) were compared. Their clinical manifestations, imaging characteristics, treatments, and prognosis were analyzed and compared. The median age of patients with COVID-19 was higher than that of patients with H1N1, and there was a higher proportion of male subjects among the H1N1 cohort (P < .05). Patients with COVID-19 exhibited higher proportions of nonproductive coughs, fatigue, and GI symptoms than those of patients with H1N1 (P < .05). Patients with H1N1 had higher Sequential Organ Failure Assessment (SOFA) scores than patients with COVID-19 (P < .05). The Pao2/Fio2 of 198.5 mm Hg in the COVID-19 cohort was significantly higher than the Pao2/Fio2 of 107.0 mm Hg in the H1N1 cohort (P < .001). Ground-glass opacities was more common in patients with COVID-19 than in patients with H1N1 (P < .001). There was a greater variety of antiviral therapies administered to COVID-19 patients than to H1N1 patients. The in-hospital mortality of patients with COVID-19 was 28.8%, whereas that of patients with H1N1 was 34.7% (P = .483). SOFA score-adjusted mortality of H1N1 patients was significantly higher than that of COVID-19 patients, with a rate ratio of 2.009 (95% CI, 1.563-2.583; P < .001). There were many differences in clinical presentations between patients with ARDS infected with either COVID-19 or H1N1. Compared with H1N1 patients, patients with COVID-19-induced ARDS had lower severity of illness scores at presentation and lower SOFA score-adjusted mortality.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Comparison of Hospitalized Patients With ARDS Caused by COVID-19 and H1N1

Tang, Xiao ; Du, Rong-Hui ; Wang, Rui ; Cao, Tan-Ze ; Guan, Lu-Lu ; Yang, Cheng-Qing ; Zhu, Qi ; Hu, Ming ; Li, Xu-Yan ; Li, Ying ; Liang, Li-Rong ; Tong, Zhao-Hui ; Sun, Bing ; Peng, Peng ; Shi, Huan-Zhong

United States: Elsevier Inc

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