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Development of epitope‐based peptide vaccine against novel coronavirus 2019 (SARS‐COV‐2): Immunoinformatics approach

Bhattacharya, Manojit ; Sharma, Ashish R. ; Patra, Prasanta ; Ghosh, Pratik ; Sharma, Garima ; Patra, Bidhan C. ; Lee, Sang‐Soo ; Chakraborty, Chiranjib

Journal of medical virology, 2020-06, Vol.92 (6), p.618-631 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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Título:
Development of epitope‐based peptide vaccine against novel coronavirus 2019 (SARS‐COV‐2): Immunoinformatics approach
Autor: Bhattacharya, Manojit ; Sharma, Ashish R. ; Patra, Prasanta ; Ghosh, Pratik ; Sharma, Garima ; Patra, Bidhan C. ; Lee, Sang‐Soo ; Chakraborty, Chiranjib
Assuntos: Amino Acid Sequence ; Antigens ; Betacoronavirus - genetics ; Betacoronavirus - immunology ; Betacoronavirus - pathogenicity ; Binding Sites ; Computational Biology - methods ; Coronaviridae ; Coronavirus Infections - immunology ; Coronavirus Infections - prevention & control ; Coronavirus Infections - virology ; Coronaviruses ; COVID-19 ; COVID-19 Vaccines ; Epitopes ; Epitopes - chemistry ; Epitopes - genetics ; Epitopes - immunology ; Epitopes, B-Lymphocyte - chemistry ; Epitopes, B-Lymphocyte - genetics ; Epitopes, B-Lymphocyte - immunology ; Epitopes, T-Lymphocyte - chemistry ; Epitopes, T-Lymphocyte - genetics ; Epitopes, T-Lymphocyte - immunology ; Glycoproteins ; Histocompatibility Antigens Class I - chemistry ; Histocompatibility Antigens Class I - genetics ; Histocompatibility Antigens Class I - immunology ; Histocompatibility Antigens Class II - chemistry ; Histocompatibility Antigens Class II - genetics ; Histocompatibility Antigens Class II - immunology ; Humans ; Immunogenicity ; immunoinformatics ; Major histocompatibility complex ; Middle East Respiratory Syndrome Coronavirus - genetics ; Middle East Respiratory Syndrome Coronavirus - immunology ; Middle East Respiratory Syndrome Coronavirus - pathogenicity ; Molecular Docking Simulation ; Pandemics - prevention & control ; Peptides ; Pneumonia, Viral - immunology ; Pneumonia, Viral - prevention & control ; Pneumonia, Viral - virology ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Structure, Tertiary ; SARS Virus - genetics ; SARS Virus - immunology ; SARS Virus - pathogenicity ; SARS-CoV-2 ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Spike glycoprotein ; Spike Glycoprotein, Coronavirus - chemistry ; Spike Glycoprotein, Coronavirus - genetics ; Spike Glycoprotein, Coronavirus - immunology ; TLR5 protein ; Toll-Like Receptor 5 - chemistry ; Toll-Like Receptor 5 - genetics ; Toll-Like Receptor 5 - immunology ; Toll-like receptors ; vaccine ; Vaccines ; Vaccines, Subunit ; Viral diseases ; Viral Vaccines - chemistry ; Viral Vaccines - immunology ; Virology
É parte de: Journal of medical virology, 2020-06, Vol.92 (6), p.618-631
Notas: Disclosures
Manojit Bhattacharya and Ashish R. Sharma contributed equally to the study.
None.
Disclosures: None.
Descrição: Recently, a novel coronavirus (SARS‐COV‐2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS‐CoV and MERS‐CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS‐COV‐2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex‐(MHC) I and 3 MHC‐II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on toll‐like receptor‐5 to get binding affinity. Therefore, to provide a fast immunogenic profile of these epitopes, we performed immunoinformatics analysis so that the rapid development of the vaccine might bring this disastrous situation to the end earlier. Highlights The potential epitopes of coronavirus (SARS‐CoV‐2) are identified. The docking complex of the construct vaccine and TLR5 is described. Peptide‐based vaccine developed and in silico validation is provided. Common epitopes of coronavirus (SARS‐CoV‐2) against B‐cells and T‐cells are listed.
Editor: United States: Wiley Subscription Services, Inc
Idioma: Inglês

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Development of epitope‐based peptide vaccine against novel coronavirus 2019 (SARS‐COV‐2): Immunoinformatics approach

Bhattacharya, Manojit ; Sharma, Ashish R. ; Patra, Prasanta ; Ghosh, Pratik ; Sharma, Garima ; Patra, Bidhan C. ; Lee, Sang‐Soo ; Chakraborty, Chiranjib

United States: Wiley Subscription Services, Inc

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