skip to main content
Idioma:

White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants

Brugulat‐Serrat, Anna ; Salvadó, Gemma ; Operto, Grégory ; Cacciaglia, Raffaele ; Sudre, Carole H. ; Grau‐Rivera, Oriol ; Suárez‐Calvet, Marc ; Falcon, Carles ; Sánchez‐Benavides, Gonzalo ; Gramunt, Nina ; Minguillon, Carolina ; Fauria, Karine ; Barkhof, Frederik ; Molinuevo, José L. ; Gispert, Juan D.

Human brain mapping, 2020-04, Vol.41 (5), p.1309-1322 [Periódico revisado por pares]

Hoboken, USA: John Wiley & Sons, Inc

Texto completo disponível

Citações Citado por
  • Título:
    White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants
  • Autor: Brugulat‐Serrat, Anna ; Salvadó, Gemma ; Operto, Grégory ; Cacciaglia, Raffaele ; Sudre, Carole H. ; Grau‐Rivera, Oriol ; Suárez‐Calvet, Marc ; Falcon, Carles ; Sánchez‐Benavides, Gonzalo ; Gramunt, Nina ; Minguillon, Carolina ; Fauria, Karine ; Barkhof, Frederik ; Molinuevo, José L. ; Gispert, Juan D.
  • Assuntos: aging ; Apolipoprotein E ; Apolipoproteins ; Cardiovascular diseases ; Cardiovascular system ; Cerebellum ; Cognition ; Cognitive ability ; Demyelination ; Executive function ; Health risks ; hypertension ; Lesions ; Mediation ; Memory ; Parameters ; prevention ; Risk analysis ; Risk factors ; Risk management ; Substantia alba ; Substantia grisea ; vascular risk factors ; white matter lesions
  • É parte de: Human brain mapping, 2020-04, Vol.41 (5), p.1309-1322
  • Notas: Funding information
    Alzheimer's Society, Grant/Award Number: AS‐JF‐17_011; European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska‐Curie action, Grant/Award Number: 752310; Instituto de Salud Carlos III, Grant/Award Number: PI12/00326; La Caixa Foundation, Grant/Award Number: LCF/PR/GN17/10300004; NIHR UCLH biomedical research centre, Grant/Award Number: NA; Secretaría de Estado de Investigación, Desarrollo e Innovación, Grant/Award Numbers: IEDI‐2016‐00690, RYC‐2013‐13054; EU/EFPIA Innovative Medicines Initiative Joint Undertaking AMYPAD, Grant/Award Numbers: 115568, #115736, #115952
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    The complete list of collaborators of the ALFA Study can be found in the acknowledgments section
    Funding information Alzheimer's Society, Grant/Award Number: AS‐JF‐17_011; European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska‐Curie action, Grant/Award Number: 752310; Instituto de Salud Carlos III, Grant/Award Number: PI12/00326; La Caixa Foundation, Grant/Award Number: LCF/PR/GN17/10300004; NIHR UCLH biomedical research centre, Grant/Award Number: NA; Secretaría de Estado de Investigación, Desarrollo e Innovación, Grant/Award Numbers: IEDI‐2016‐00690, RYC‐2013‐13054; EU/EFPIA Innovative Medicines Initiative Joint Undertaking AMYPAD, Grant/Award Numbers: 115568, #115736, #115952
    Anna Brugulat‐Serrat, Gemma Salvadó contributed equally to the manuscript
  • Descrição: White matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This study explored whether WMH lesion volume mediates the relationship between cerebral patterns of GMv and cognition in 521 (mean age 57.7 years) cognitively unimpaired middle‐aged individuals. Episodic memory (EM) was measured with the Memory Binding Test and executive functions (EF) using five WAIS‐IV subtests. WMH were automatically determined from T2 and FLAIR sequences and characterized using diffusion‐weighted imaging (DWI) parameters. WMH volume was entered as a mediator in a voxel‐wise mediation analysis relating GMv and cognitive performance (with both EM and EF composites and the individual tests independently). The mediation model was corrected by age, sex, education, number of Apolipoprotein E (APOE)‐ε4 alleles and total intracranial volume. We found that even at very low levels of WMH burden in the cohort (median volume of 3.2 mL), higher WMH lesion volume was significantly associated with a widespread pattern of lower GMv in temporal, frontal, and cerebellar areas. WMH mediated the relationship between GMv and EF, mainly driven by processing speed, but not EM. DWI parameters in these lesions were compatible with incipient demyelination and axonal loss. These findings lead to the reflection on the relevance of the control of cardiovascular risk factors in middle‐aged individuals as a valuable preventive strategy to reduce or delay cognitive decline.
  • Editor: Hoboken, USA: John Wiley & Sons, Inc
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.