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Fecal microbiota transplantation therapy for Parkinson's disease: A preliminary study

Xue, Liu-Jun ; Yang, Xiao-Zhong ; Tong, Qiang ; Shen, Peng ; Ma, Shi-Jie ; Wu, Shang-Nong ; Zheng, Jin-Long ; Wang, Hong-Gang

Medicine (Baltimore), 2020-08, Vol.99 (35), p.e22035-e22035 [Periódico revisado por pares]

United States: Lippincott Williams & Wilkins

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Título:
Fecal microbiota transplantation therapy for Parkinson's disease: A preliminary study
Autor: Xue, Liu-Jun ; Yang, Xiao-Zhong ; Tong, Qiang ; Shen, Peng ; Ma, Shi-Jie ; Wu, Shang-Nong ; Zheng, Jin-Long ; Wang, Hong-Gang
Assuntos: Aged ; Colonoscopy ; Fecal Microbiota Transplantation - adverse effects ; Fecal Microbiota Transplantation - methods ; Fecal Microbiota Transplantation - statistics & numerical data ; Female ; Humans ; Intubation, Gastrointestinal ; Male ; Middle Aged ; Observational Study ; Parkinson Disease - therapy ; Patient Satisfaction ; Pilot Projects ; Young Adult
É parte de: Medicine (Baltimore), 2020-08, Vol.99 (35), p.e22035-e22035
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Imbalances in the gut microbiota mediate the progression of neurodegenerative diseases such as Parkinson's disease (PD). Fecal microbiota transplantation (FMT) is currently being explored as a potential therapy for PD. The objective of this study was to assess the efficacy and safety of FMT on PD. Fifteen PD patients were included, 10 of them received FMT via colonoscopy (colonic FMT group) and 5 received FMT via nasal-jejunal tube (nasointestinal FMT group). The score of PSQI, HAMD, HAMA, PDQ-39, NMSQ and UPDRS-III significantly decreased after FMT treatment (all P < .05). Colonic FMT group showed significant improvement and longer maintenance of efficacy compared with nasointestinal FMT (P = .002). Two patients achieved self-satisfying outcomes that last for more than 24 months. However, nasointestinal FMT group had no significant therapeutic effect, although UPDRS-III score slightly reduced. There were no patients were satisfied with nasointestinal FMT for more than 3 months. Among 15 PD patients, there were 5 cases had adverse events (AEs), including diarrhea (2 cases), abdominal pain (2 cases) and flatulence (1 case). These AEs were mild and self-limiting. We conclude that FMT can relieve the motor and non-motor symptoms with acceptable safety in PD. Compared with nasointestinal FMT, colonic FMT seems better and preferable.
Editor: United States: Lippincott Williams & Wilkins
Idioma: Inglês

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Fecal microbiota transplantation therapy for Parkinson's disease: A preliminary study

Xue, Liu-Jun ; Yang, Xiao-Zhong ; Tong, Qiang ; Shen, Peng ; Ma, Shi-Jie ; Wu, Shang-Nong ; Zheng, Jin-Long ; Wang, Hong-Gang

United States: Lippincott Williams & Wilkins

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