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Default mode network activity in bipolar disorder

Zovetti, Niccolò ; Rossetti, Maria Gloria ; Perlini, Cinzia ; Maggioni, Eleonora ; Bontempi, Pietro ; Bellani, Marcella ; Brambilla, Paolo

Epidemiology and psychiatric sciences, 2020-01, Vol.29, p.e166-e166, Article e166 [Periódico revisado por pares]

Cambridge, UK: Cambridge University Press

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  • Título:
    Default mode network activity in bipolar disorder
  • Autor: Zovetti, Niccolò ; Rossetti, Maria Gloria ; Perlini, Cinzia ; Maggioni, Eleonora ; Bontempi, Pietro ; Bellani, Marcella ; Brambilla, Paolo
  • Assuntos: Bipolar disorder ; Blood ; Epidemiology for Behavioural Neurosciences ; Memory ; Neurobiology ; Psychiatry ; Psychosis
  • É parte de: Epidemiology and psychiatric sciences, 2020-01, Vol.29, p.e166-e166, Article e166
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    Both authors contributed equally to this work.
  • Descrição: Since its discovery in 1997, the default mode network (DMN) and its components have been extensively studied in both healthy individuals and psychiatric patients. Several studies have investigated possible DMN alterations in specific mental conditions such as bipolar disorder (BD). In this review, we describe current evidence from resting-state functional magnetic resonance imaging studies with the aim to understand possible changes in the functioning of the DMN in BD. Overall, several types of analyses including seed-based and independent component have been conducted on heterogeneous groups of patients highlighting different results. Despite the differences, findings seem to indicate that BD is associated with alterations in both frontal and posterior DMN structures, mainly in the prefrontal, posterior cingulate and inferior parietal cortices. We conclude this review by suggesting possible future research directions.
  • Editor: Cambridge, UK: Cambridge University Press
  • Idioma: Inglês;Italiano
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