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What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology

Altulea, Dania ; Maassen, Sjors ; Baranov, Maksim V ; van den Bogaart, Geert Wu, Jiarui

Journal of molecular cell biology, 2021-03, Vol.13 (3), p.175-184 [Periódico revisado por pares]

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Título:
What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology
Autor: Altulea, Dania ; Maassen, Sjors ; Baranov, Maksim V ; van den Bogaart, Geert
Wu, Jiarui
Assuntos: Reviews
É parte de: Journal of molecular cell biology, 2021-03, Vol.13 (3), p.175-184
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of SARS-CoV-2 in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of COVID-19. However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.
Editor: United States: Oxford University Press
Idioma: Inglês

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