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Soluble Angiotensin-Converting Enzyme 2, Cardiac Biomarkers, Structure, and Function, and Cardiovascular Events (from the Atherosclerosis Risk in Communities Study)

Hussain, Aliza ; Tang, Olive ; Sun, Caroline ; Jia, Xiaoming ; Selvin, Elizabeth ; Nambi, Vijay ; Folsom, Aaron ; Heiss, Gerardo ; Zannad, Faiez ; Mosley, Thomas ; Virani, Salim S. ; Coresh, Josef ; Boerwinkle, Eric ; Yu, Bing ; Cunningham, Jonathan W. ; Shah, Amil M. ; Solomon, Scott D. ; de Lemos, James A. ; Hoogeveen, Ron C. ; Ballantyne, Christie M.

The American journal of cardiology, 2021-05, Vol.146, p.15-21 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Soluble Angiotensin-Converting Enzyme 2, Cardiac Biomarkers, Structure, and Function, and Cardiovascular Events (from the Atherosclerosis Risk in Communities Study)
Autor: Hussain, Aliza ; Tang, Olive ; Sun, Caroline ; Jia, Xiaoming ; Selvin, Elizabeth ; Nambi, Vijay ; Folsom, Aaron ; Heiss, Gerardo ; Zannad, Faiez ; Mosley, Thomas ; Virani, Salim S. ; Coresh, Josef ; Boerwinkle, Eric ; Yu, Bing ; Cunningham, Jonathan W. ; Shah, Amil M. ; Solomon, Scott D. ; de Lemos, James A. ; Hoogeveen, Ron C. ; Ballantyne, Christie M.
Assuntos: ACE2 ; Aged ; Aldosterone ; Angiotensin ; Angiotensin-converting enzyme 2 ; Angiotensin-Converting Enzyme 2 - blood ; Arteriosclerosis ; Atherosclerosis ; Atherosclerosis - blood ; Atherosclerosis - diagnosis ; Atherosclerosis - physiopathology ; Automation ; Biomarkers ; Biomarkers - blood ; Blood pressure ; Brain natriuretic peptide ; Calcium-binding protein ; Cardiology and cardiovascular system ; Cardiovascular diseases ; Confidence intervals ; Congestive heart failure ; Conversion ; Diabetes ; Diabetes mellitus ; Enzymes ; Female ; Follow-Up Studies ; Heart diseases ; Heart Ventricles - diagnostic imaging ; Heart Ventricles - physiopathology ; Hospitalization ; Human health and pathology ; Humans ; Hypertension ; Immunoassay ; Life Sciences ; Male ; Middle Aged ; Peptidyl-dipeptidase A ; Regression analysis ; Renin ; Renin-Angiotensin System - physiology ; Reproducibility ; Risk ; Risk Factors ; Statistical analysis ; Stroke ; Structure-function relationships ; Time Factors ; Troponin ; Troponin I ; Variables ; Ventricle ; Ventricular Function, Left - physiology
É parte de: The American journal of cardiology, 2021-05, Vol.146, p.15-21
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMCID: PMC8038970
Author contributions: AH made substantial contributions to the conception and design of the work, interpretation of data, and drafting of the manuscript. CS made substantial contributions to the analysis and interpretation of data for the manuscript. OT, XJ, ES, VN, AF, GH, FZ, TM, SSV, JC, EB, BY, JWC, AMS, SDS, and JAdL contributed to the interpretation of the data, revising it critically for important intellectual content. RCH and CMB made substantial contributions to the conception and design of the work, interpretation of data and ensuring that questions related to the accuracy or integrity of any part of the work were appropriately investigated and resolved.
CRediT Author Statement
Descrição: Membrane-bound angiotensin-converting enzyme 2 is important in regulation of the renin–angiotensin–aldosterone system, but the association of cleaved soluble ACE2 (sACE2) with cardiovascular disease (CVD) is unclear. We evaluated the association of sACE2 with cardiac biomarkers, structure, and function and cardiovascular events in the Atherosclerosis Risk in Communities Study. sACE2 was measured in a subset of 497 participants (mean age 78±5.4 years, 53% men, 27% black); Cox regression analyses assessed prospective associations of sACE2 with time to first CVD event at median 6.1-year follow-up. sACE2 was higher in men, blacks, and participants with prevalent CVD, diabetes, or hypertension. Higher sACE2 levels were associated with significantly higher biomarkers of cardiac injury (high-sensitivity cardiac troponin I and T, N-terminal pro–B-type natriuretic peptide), greater left ventricular mass index, and impaired diastolic function in linear regression analyses, and with increased risk for heart failure hospitalization (adjusted hazard ratio per natural log unit increase [HR] 1.32, 95% confidence interval [CI] 1.10 to 1.58), CVD events (HR 1.34, 95% CI 1.13 to 1.60), and all-cause death (HR 1.26, 95% CI 1.01 to 1.57). In an elderly biracial cohort, sACE2 was positively associated with biomarkers reflecting myocardial injury and neurohormonal activation, left ventricular mass index, impaired diastolic function, CVD, events and all-cause death.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Soluble Angiotensin-Converting Enzyme 2, Cardiac Biomarkers, Structure, and Function, and Cardiovascular Events (from the Atherosclerosis Risk in Communities Study)

United States: Elsevier Inc

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