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Phylogenetically diverse diets favor more complex venoms in North American pitvipers

Holding, Matthew L ; Strickland, Jason L ; Rautsaw, Rhett M ; Hofmann, Erich P ; Mason, Andrew J ; Hogan, Michael P ; Nystrom, Gunnar S ; Ellsworth, Schyler A ; Colston, Timothy J ; Borja, Miguel ; Castañeda-Gaytán, Gamaliel ; Grünwald, Christoph I ; Jones, Jason M ; Freitas-de-Sousa, Luciana A ; Viala, Vincent Louis ; Margres, Mark J ; Hingst-Zaher, Erika ; Junqueira-de-Azevedo, Inácio L M ; Moura-da-Silva, Ana M ; Grazziotin, Felipe G ; Gibbs, H Lisle ; Rokyta, Darin R ; Parkinson, Christopher L

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (17), p.1 [Periódico revisado por pares]

United States: National Academy of Sciences

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Título:
Phylogenetically diverse diets favor more complex venoms in North American pitvipers
Autor: Holding, Matthew L ; Strickland, Jason L ; Rautsaw, Rhett M ; Hofmann, Erich P ; Mason, Andrew J ; Hogan, Michael P ; Nystrom, Gunnar S ; Ellsworth, Schyler A ; Colston, Timothy J ; Borja, Miguel ; Castañeda-Gaytán, Gamaliel ; Grünwald, Christoph I ; Jones, Jason M ; Freitas-de-Sousa, Luciana A ; Viala, Vincent Louis ; Margres, Mark J ; Hingst-Zaher, Erika ; Junqueira-de-Azevedo, Inácio L M ; Moura-da-Silva, Ana M ; Grazziotin, Felipe G ; Gibbs, H Lisle ; Rokyta, Darin R ; Parkinson, Christopher L
Assuntos: Adaptation, Biological - genetics ; Animals ; Biological Sciences ; Coagulation ; Comparative analysis ; Complexity ; Crotalinae - genetics ; Crotalinae - metabolism ; Diet ; Diet - trends ; Diet - veterinary ; Divergence ; Evolution ; Gene Expression - genetics ; Gene families ; Genomes ; Natural selection ; North America ; Phylogenetics ; Phylogeny ; Predators ; Predatory Behavior - physiology ; Prey ; Proteomics ; Proteomics - methods ; Selection, Genetic - genetics ; Snake Venoms - genetics ; Snake Venoms - metabolism ; Snakes ; Species diversity ; Tooth - metabolism ; Transcriptome - genetics ; Venom ; Venomous snakes
É parte de: Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (17), p.1
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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2Present address: Department of Biology, University of South Alabama, Mobile, AL 36688.
5Present address: Department of Integrative Biology, University of South Florida, Tampa, FL 33620.
Author contributions: M.L.H., J.L.S., R.M.R., E.P.H., A.J.M., M.P.H., T.J.C., M.B., G.C.-G., C.I.G., J.M.J., M.J.M., E.H.-Z., I.L.M.J.-d.-A., A.M.M.-d.-S., F.G.G., H.L.G., D.R.R., and C.L.P. designed research; M.L.H., J.L.S., R.M.R., E.P.H., A.J.M., M.P.H., G.S.N., S.A.E., T.J.C., M.B., G.C.-G., C.I.G., J.M.J., L.A.F.-d.-S., V.L.V., M.J.M., E.H.-Z., I.L.M.J.-d.-A., F.G.G., D.R.R., and C.L.P. performed research; D.R.R. contributed new reagents/analytic tools; M.L.H., J.L.S., R.M.R., E.P.H., A.J.M., G.S.N., S.A.E., T.J.C., L.A.F.-d.-S., M.J.M., I.L.M.J.-d.-A., and F.G.G. analyzed data; and M.L.H., J.L.S., R.M.R., A.J.M., M.J.M., A.M.M.-d.-S., F.G.G., H.L.G., D.R.R., and C.L.P. wrote the paper.
4Present address: Department of Biology, University of Florida, Gainesville, FL 32611.
Edited by Jonathan B. Losos, Washington University in St. Louis, St. Louis, MO, and approved February 9, 2021 (received for review July 28, 2020)
3Present address: Science Department, Cape Fear Community College, Wilmington, NC 28401.
Descrição: The role of natural selection in the evolution of trait complexity can be characterized by testing hypothesized links between complex forms and their functions across species. Predatory venoms are composed of multiple proteins that collectively function to incapacitate prey. Venom complexity fluctuates over evolutionary timescales, with apparent increases and decreases in complexity, and yet the causes of this variation are unclear. We tested alternative hypotheses linking venom complexity and ecological sources of selection from diet in the largest clade of front-fanged venomous snakes in North America: the rattlesnakes, copperheads, cantils, and cottonmouths. We generated independent transcriptomic and proteomic measures of venom complexity and collated several natural history studies to quantify dietary variation. We then constructed genome-scale phylogenies for these snakes for comparative analyses. Strikingly, prey phylogenetic diversity was more strongly correlated to venom complexity than was overall prey species diversity, specifically implicating prey species' divergence, rather than the number of lineages alone, in the evolution of complexity. Prey phylogenetic diversity further predicted transcriptomic complexity of three of the four largest gene families in viper venom, showing that complexity evolution is a concerted response among many independent gene families. We suggest that the phylogenetic diversity of prey measures functionally relevant divergence in the targets of venom, a claim supported by sequence diversity in the coagulation cascade targets of venom. Our results support the general concept that the diversity of species in an ecological community is more important than their overall number in determining evolutionary patterns in predator trait complexity.
Editor: United States: National Academy of Sciences
Idioma: Inglês

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Phylogenetically diverse diets favor more complex venoms in North American pitvipers

United States: National Academy of Sciences

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