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Heartbeats entrain breathing via baroreceptor‐mediated modulation of expiratory activity

Barnett, William H. ; Baekey, David M. ; Paton, Julian F. R. ; Dick, Thomas E. ; Wehrwein, Erica A. ; Molkov, Yaroslav I.

Experimental physiology, 2021-05, Vol.106 (5), p.1181-1195 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

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  • Título:
    Heartbeats entrain breathing via baroreceptor‐mediated modulation of expiratory activity
  • Autor: Barnett, William H. ; Baekey, David M. ; Paton, Julian F. R. ; Dick, Thomas E. ; Wehrwein, Erica A. ; Molkov, Yaroslav I.
  • Assuntos: Analysis ; Animals ; arterial baroreflex ; Baroreceptors ; Baroreflex ; Blood Pressure ; Brain stem ; coupling ; CVC ; EKG ; Electrocardiogram ; Electrocardiography ; Heart Rate ; Humans ; Latency ; Male ; mathematical modeling ; Mechanical ventilation ; Neurons ; Perfusion ; Pressoreceptors - physiology ; Reflexes ; Respiration
  • É parte de: Experimental physiology, 2021-05, Vol.106 (5), p.1181-1195
  • Notas: This article was first published as a preprint. Barnett, W. H., Baekey, D. M., Paton, J. F. R., Dick, T. E., Wehrwein, E. A., & Molkov, Y. I. 2020. Heartbeats entrain breathing via baroreceptor‐mediated modulation of expiratory activity. bioRxiv. doi
    Thomas E. Dick, Erica A. Wehrwein and Yaroslav I. Molkov shared senior authorship.
    Edited by: Robert Brothers
    10.1101/2020.12.09.416776
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    AUTHOR CONTRIBUTIONS
    The human studies were performed by E.A.W. at the Mayo Clinic, Rochester, MN, USA. Animal studies were performed by D.M.B. at the University of Bristol, UK. Conception or design of the work: W.H.B., T.E.D. and Y.I.M. Acquisition, analysis or interpretation of data for the work: W.H.B., D.M.B., J.F.R.P., T.E.D., E.A.W. and Y.I.M. Drafting of the work or revising it critically for important intellectual content: W.H.B., D.M.B., J.F.R.P., T.E.D., E.A.W. and Y.I.M. All authors have read and approved the final version of this manuscript and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All persons designated as authors qualify for authorship, and all those who qualify for authorship are listed.
  • Descrição: New Findings  Cardio‐ventilatory coupling refers to the onset of inspiration occurring at a preferential latency following the last heartbeat (HB) in expiration. According to the cardiac‐trigger hypothesis, the pulse pressure initiates an inspiration via baroreceptor activation. However, the central neural substrate mediating this coupling remains undefined. Using a combination of animal data, human data and mathematical modelling, this study tests the hypothesis that the HB, by way of pulsatile baroreflex activation, controls the initiation of inspiration that occurs through a rapid neural activation loop from the carotid baroreceptors to Bötzinger complex expiratory neurons. Cardio‐ventilatory coupling refers to a heartbeat (HB) occurring at a preferred latency prior to the next breath. We hypothesized that the pressure pulse generated by a HB activates baroreceptors that modulate brainstem expiratory neuronal activity and delay the initiation of inspiration. In supine male subjects, we recorded ventilation, electrocardiogram and blood pressure during 20‐min epochs of baseline, slow–deep breathing and recovery. In in situ rodent preparations, we recorded brainstem activity in response to pulses of perfusion pressure. We applied a well‐established respiratory network model to interpret these data. In humans, the latency between a HB and onset of inspiration was consistent across different breathing patterns. In in situ preparations, a transient pressure pulse during expiration activated a subpopulation of expiratory neurons normally active during post‐inspiration, thus delaying the next inspiration. In the model, baroreceptor input to post‐inspiratory neurons accounted for the effect. These studies are consistent with baroreflex activation modulating respiration through a pauci‐synaptic circuit from baroreceptors to onset of inspiration.
  • Editor: England: Wiley Subscription Services, Inc
  • Idioma: Inglês
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