skip to main content
Idioma:
Primo Advanced Search
Primo Advanced Search Query Term
Primo Advanced Search prefilters
Busca Simples

A more sustainable isothiocyanate synthesis by amine catalyzed sulfurization of isocyanides with elemental sulfur

Nickisch, R ; Conen, P ; Gabrielsen, S. M ; Meier, M. A. R

RSC advances, 2021-01, Vol.11 (5), p.3134-3142 [Periódico revisado por pares]

England: Royal Society of Chemistry

Texto completo disponível

Citações Citado por
  • Título:
    A more sustainable isothiocyanate synthesis by amine catalyzed sulfurization of isocyanides with elemental sulfur
  • Autor: Nickisch, R ; Conen, P ; Gabrielsen, S. M ; Meier, M. A. R
  • Assuntos: Amines ; Butyrolactone ; Catalytic converters ; Chemical synthesis ; Chemistry ; Column chromatography ; Reagents ; Sulfur ; Sulfurization ; Sustainability
  • É parte de: RSC advances, 2021-01, Vol.11 (5), p.3134-3142
  • Notas: 10.1039/d0ra10436a
    Electronic supplementary information (ESI) available. See DOI
  • Descrição: Isothiocyanates (ITCs) are typically prepared using amines and highly toxic reagents such as thiophosgene, its derivatives, or CS 2 . In this work, an investigation of a multicomponent reaction (MCR) using isocyanides, elemental sulfur and amines revealed that isocyanides can be converted to isothiocyanates using sulfur and catalytic amounts of amine bases, especially DBU (down to 2 mol%). This new catalytic reaction was optimized in terms of sustainability, especially considering benign solvents such as Cyrene™ or γ-butyrolactone (GBL) under moderate heating (40 °C). Purification by column chromatography was further optimized to generate less waste by maintaining high purity of the product. Thus, E -factors as low as 0.989 were achieved and the versatility of this straightforward procedure was shown by converting 20 different isocyanides under catalytic conditions, while obtaining moderate to high yields (34-95%). Isothiocyanates were snythesized in a more sustainable manner by sulfurization of isocyanides with elemental sulfur using catalytic amounts of DBU (down to 2 mol%).
  • Editor: England: Royal Society of Chemistry
  • Idioma: Inglês
Links
Voltar para lista de resultados
Ir para página anteriorAnterior Resultado  7 AvançarIr para próxima página

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.