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Recent Advances in Software Tools for More Generic and Precise Intact Glycopeptide Analysis

Cao, Weiqian ; Liu, Mingqi ; Kong, Siyuan ; Wu, Mengxi ; Zhang, Yang ; Yang, Pengyuan

Molecular & cellular proteomics, 2021, Vol.20, p.100060-100060, Article 100060 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Recent Advances in Software Tools for More Generic and Precise Intact Glycopeptide Analysis
  • Autor: Cao, Weiqian ; Liu, Mingqi ; Kong, Siyuan ; Wu, Mengxi ; Zhang, Yang ; Yang, Pengyuan
  • Assuntos: Animals ; bottom-up experimental strategies ; Glycopeptides - analysis ; Humans ; intact glycopeptide analysis ; Mass Spectrometry ; Proteomics ; quality control ; Review ; Software ; software applications ; software tools
  • É parte de: Molecular & cellular proteomics, 2021, Vol.20, p.100060-100060, Article 100060
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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    ObjectType-Undefined-3
  • Descrição: Intact glycopeptide identification has long been known as a key and challenging barrier to the comprehensive and accurate understanding the role of glycosylation in an organism. Intact glycopeptide analysis is a blossoming field that has received increasing attention in recent years. MS-based strategies and relative software tools are major drivers that have greatly facilitated the analysis of intact glycopeptides, particularly intact N-glycopeptides. This article provides a systematic review of the intact glycopeptide-identification process using MS data generated in shotgun proteomic experiments, which typically focus on N-glycopeptide analysis. Particular attention is paid to the software tools that have been recently developed in the last decade for the interpretation and quality control of glycopeptide spectra acquired using different MS strategies. The review also provides information about the characteristics and applications of these software tools, discusses their advantages and disadvantages, and concludes with a discussion of outstanding tools. [Display omitted] •Summarize the development of software tools for intact glycopeptide analysis.•Survey the MS acquisition strategies for glycopeptide spectrum acquisition.•Conclude the quality control methods for glycopeptide-spectrum matching.•Show the application of intact glycopeptide analysis in glycoproteomic research. This article provides a systematic review of the most recent MS-based strategies and corresponding software tools for the analysis of intact glycopeptides, particularly intact N-glycopeptides, reported in the last decade, including the process of identifying N-glycopeptides from MS data, the existing methods of MS data acquisition and interpretation, the quality control methods, the display of results, and the software applications.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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