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Y380Q novel mutation in receptor-binding domain of SARS-CoV-2 spike protein together with C379W interfere in the neutralizing antibodies interaction

Sartor, Ivaine Tais Sauthier ; Varela, Fernanda Hammes ; Meireles, Mariana Rost ; Kern, Luciane Beatriz ; Azevedo, Thaís Raupp ; Giannini, Gabriela Luchiari Tumioto ; da Silva, Mariana Soares ; Demoliner, Meriane ; Gularte, Juliana Schons ; de Almeida, Paula Rodrigues ; Fleck, Juliane Deise ; Zavaglia, Gabriela Oliveira ; Fernandes, Ingrid Rodrigues ; de David, Caroline Nespolo ; Santos, Amanda Paz ; de Almeida, Walquiria Aparecida Ferreira ; Porto, Victor Bertollo Gomes ; Scotta, Marcelo Comerlato ; Vieira, Gustavo Fioravanti ; Spilki, Fernando Rosado ; Stein, Renato T. ; Polese-Bonatto, Márcia

Diagnostic microbiology and infectious disease, 2022-04, Vol.102 (4), p.115636-115636, Article 115636 [Peer Reviewed Journal]

United States: Elsevier Inc

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Title:
Y380Q novel mutation in receptor-binding domain of SARS-CoV-2 spike protein together with C379W interfere in the neutralizing antibodies interaction
Author: Sartor, Ivaine Tais Sauthier ; Varela, Fernanda Hammes ; Meireles, Mariana Rost ; Kern, Luciane Beatriz ; Azevedo, Thaís Raupp ; Giannini, Gabriela Luchiari Tumioto ; da Silva, Mariana Soares ; Demoliner, Meriane ; Gularte, Juliana Schons ; de Almeida, Paula Rodrigues ; Fleck, Juliane Deise ; Zavaglia, Gabriela Oliveira ; Fernandes, Ingrid Rodrigues ; de David, Caroline Nespolo ; Santos, Amanda Paz ; de Almeida, Walquiria Aparecida Ferreira ; Porto, Victor Bertollo Gomes ; Scotta, Marcelo Comerlato ; Vieira, Gustavo Fioravanti ; Spilki, Fernando Rosado ; Stein, Renato T. ; Polese-Bonatto, Márcia
Subjects: Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; Child ; COVID-19 ; Humans ; Infant ; Mutation ; Novel mutation ; Protein Binding ; RBD ; SARS-CoV-2 ; SARS-CoV-2 - genetics ; Spike Glycoprotein, Coronavirus - genetics ; Variants
Is Part Of: Diagnostic microbiology and infectious disease, 2022-04, Vol.102 (4), p.115636-115636, Article 115636
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to the first authorship of this manuscript.
Description: We aimed to describe the SARS-CoV-2 lineages circulating early pandemic among samples with S gene dropout and characterize the receptor-binding domain (RBD) of viral spike protein. Adults and children older than 2 months with signs and symptoms of COVID-19 were prospectively enrolled from May to October in Porto Alegre, Brazil. All participants performed RT-PCR assay, and samples with S gene dropout and cycle threshold < 30 were submitted to high-throughput sequencing (HTS). 484 out of 1,557 participants tested positive for SARS-CoV-2. The S gene dropout was detected in 7.4% (36/484) and a peak was observed in August. The B.1.1.28, B.1.91 and B.1.1.33 lineages were circulating in early pandemic. The RBD novel mutation (Y380Q) was found in one sample occurring simultaneously with C379W and V395A, and the B.1.91 lineage in the spike protein. The Y380Q and C379W may interfere with the binding of neutralizing antibodies (CR3022, EY6A, H014, S304).
Publisher: United States: Elsevier Inc
Language: English

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Y380Q novel mutation in receptor-binding domain of SARS-CoV-2 spike protein together with C379W interfere in the neutralizing antibodies interaction

United States: Elsevier Inc

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