Idioma:

First report of methicillin-resistant Staphylococcus aureus with reduced susceptibility to vancomycin in Thailand

TRAKULSOMBOON, Suwanna ; DANCHAIVIJITR, Somwang ; RONGRUNGRUANG, Yong ; DHIRAPUTRA, Chertsak ; SUSAEMGRAT, Wattanachai ; ITO, Teruyo ; HIRAMATSU, Keiichi

Journal of clinical microbiology, 2001-02, Vol.39 (2), p.591-595 [Periódico revisado por pares]

Washington, DC: American Society for Microbiology

Texto completo disponível

Citações Citado por

Enviar para

Título:
First report of methicillin-resistant Staphylococcus aureus with reduced susceptibility to vancomycin in Thailand
Autor: TRAKULSOMBOON, Suwanna ; DANCHAIVIJITR, Somwang ; RONGRUNGRUANG, Yong ; DHIRAPUTRA, Chertsak ; SUSAEMGRAT, Wattanachai ; ITO, Teruyo ; HIRAMATSU, Keiichi
Assuntos: Adolescent ; Aged ; Anti-Bacterial Agents - pharmacology ; Bacteriology ; Biological and medical sciences ; DNA, Bacterial - genetics ; DNA, Bacterial - isolation & purification ; Electrophoresis, Gel, Pulsed-Field ; Epidemiology ; Fatal Outcome ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Methicillin Resistance ; Microbial Sensitivity Tests ; Microbiology ; Middle Aged ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - microbiology ; Staphylococcus aureus ; Staphylococcus aureus - classification ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - isolation & purification ; Teicoplanin - pharmacology ; Thailand ; Vancomycin - pharmacology
É parte de: Journal of clinical microbiology, 2001-02, Vol.39 (2), p.591-595
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Case Study-2
ObjectType-Feature-4
ObjectType-Report-1
ObjectType-Article-3
Corresponding author. Mailing address: Department of Bacteriology, Juntendo University, 2-1-1 Hongo, Bukyo-Ku, Tokyo, Japan 113-8421. Phone: 81-3-5802-1040. Fax: 81-3-5684-7830. E-mail: hiram@med.juntendo.ac.jp.
Descrição: To investigate whether there are methicillin-resistant Staphylococcus aureus (MRSA) strains with reduced susceptibility to vancomycin in Thailand, a total of 155 MRSA strains isolated from patients hospitalized between 1988 and 1999 in university hospitals in Thailand were tested for glycopeptide susceptibility. All the strains were classified as susceptible to vancomycin and teicoplanin when judged by NCCLS criteria for glycopeptide susceptibility using the agar dilution MIC determination. Vancomycin MICs at which 50 and 90% of the isolates tested were inhibited (MIC50 and MIC(90), respectively) were 0.5 and 1 microg/ml, respectively, with a range of 0.25 to 2 microg/ml. For teicoplanin, MIC50 and MIC90 were 2 microg/ml, with a range of 0.5 to 4 microg/ml. However, one-point population analysis identified three MRSA strains, MR135, MR187, and MR209, which contained subpopulations of cells that could grow in 4 microg of vancomycin per ml. The proportions of the subpopulations were 2 x 10(-4), 1.5 x 10(-6), and 4 x 10(-7), respectively. The subsequent performance of a complete population analysis and testing for the emergence of mutants with reduced susceptibility to vancomycin (MIC > or = 8 microg/ml) confirmed that these strains were heterogeneously resistant to vancomycin. Two of these strains caused infection that was refractory to vancomycin therapy. Pulsed-field gel electrophoresis showed that the two strains had identical SmaI macrorestriction patterns and that they were one of the common types of MRSA isolated in the hospital. This is the first report of heterogeneous resistance to vancomycin in Thailand and an early warning for the possible emergence of vancomycin resistance in S. aureus in Southeast Asia.
Editor: Washington, DC: American Society for Microbiology
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 10 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

First report of methicillin-resistant Staphylococcus aureus with reduced susceptibility to vancomycin in Thailand

TRAKULSOMBOON, Suwanna ; DANCHAIVIJITR, Somwang ; RONGRUNGRUANG, Yong ; DHIRAPUTRA, Chertsak ; SUSAEMGRAT, Wattanachai ; ITO, Teruyo ; HIRAMATSU, Keiichi

Washington, DC: American Society for Microbiology

Buscando em bases de dados remotas. Favor aguardar.