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PUFA ω-3 and ω-6 biomarkers and sleep: a pooled analysis of cohort studies on behalf of the Fatty Acids and Outcomes Research Consortium (FORCE)

Murphy, Rachel A ; Tintle, Nathan ; Harris, William S ; Darvishian, Maryam ; Marklund, Matti ; Virtanen, Jyrki K ; Hantunen, Sari ; de Mello, Vanessa D ; Tuomilehto, Jaakko ; Lindström, Jaana ; Bolt, Matthew A ; Brouwer, Ingeborg A ; Wood, Alexis C ; Senn, Mackenzie ; Redline, Susan ; Tsai, Michael Y ; Gudnason, Vilmundur ; Eiriksdottir, Gudny ; Lindberg, Eva ; Shadyab, Aladdin H ; Liu, Buyun ; Carnethon, Mercedes ; Uusitupa, Matti ; Djousse, Luc ; Risérus, Ulf ; Lind, Lars ; van Dam, Rob M ; Koh, Woon-Puay ; Shi, Peilin ; Siscovick, David ; Lemaitre, Rozenn N ; Mozaffarian, Dariush

The American journal of clinical nutrition, 2022-03, Vol.115 (3), p.864-876 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
PUFA ω-3 and ω-6 biomarkers and sleep: a pooled analysis of cohort studies on behalf of the Fatty Acids and Outcomes Research Consortium (FORCE)
Autor: Murphy, Rachel A ; Tintle, Nathan ; Harris, William S ; Darvishian, Maryam ; Marklund, Matti ; Virtanen, Jyrki K ; Hantunen, Sari ; de Mello, Vanessa D ; Tuomilehto, Jaakko ; Lindström, Jaana ; Bolt, Matthew A ; Brouwer, Ingeborg A ; Wood, Alexis C ; Senn, Mackenzie ; Redline, Susan ; Tsai, Michael Y ; Gudnason, Vilmundur ; Eiriksdottir, Gudny ; Lindberg, Eva ; Shadyab, Aladdin H ; Liu, Buyun ; Carnethon, Mercedes ; Uusitupa, Matti ; Djousse, Luc ; Risérus, Ulf ; Lind, Lars ; van Dam, Rob M ; Koh, Woon-Puay ; Shi, Peilin ; Siscovick, David ; Lemaitre, Rozenn N ; Mozaffarian, Dariush
Assuntos: Arachidonic acid ; Biomarkers ; Cohort analysis ; Cohort Studies ; Consortia ; Cross-Sectional Studies ; diet ; Fatty Acids ; Fatty Acids, Omega-3 ; Humans ; Linoleic acid ; Linolenic acid ; omega-3 ; Original Research Communications ; Outcome Assessment, Health Care ; Polyunsaturated fatty acids ; public health ; Sleep ; sleep quality ; Variance analysis
É parte de: The American journal of clinical nutrition, 2022-03, Vol.115 (3), p.864-876
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: n-3 and n-6 PUFAs have physiologic roles in sleep processes, but little is known regarding circulating n-3 and n-6 PUFA and sleep parameters. We sought to assess associations between biomarkers of n-3 and n-6 PUFA intake with self-reported sleep duration and difficulty falling asleep in the Fatty Acids and Outcome Research Consortium. Harmonized, de novo, individual-level analyses were performed and pooled across 12 cohorts. Participants were 35–96 y old and from 5 nations. Circulating measures included α-linolenic acid (ALA), EPA, docosapentaenoic acid (DPA), DHA, EPA + DPA + DHA, linoleic acid, and arachidonic acid. Sleep duration (10 cohorts, n = 18,791) was categorized as short (≤6 h), 7–8 h (reference), or long (≥9 h). Difficulty falling asleep (8 cohorts, n = 12,500) was categorized as yes or no. Associations between PUFAs, sleep duration, and difficulty falling asleep were assessed by cross-sectional multinomial logistic regression using standardized protocols and covariates. Cohort-specific multivariable-adjusted ORs per quintile of PUFAs were pooled with inverse–variance weighted meta-analysis. In pooled analysis adjusted for sociodemographic characteristics and health status, participants with higher very long-chain n-3 PUFAs were less likely to have long sleep duration. In the top compared with the bottom quintiles, the multivariable-adjusted ORs (95% CIs) for long sleep were 0.78 (95% CI: 0.65, 0.95) for DHA and 0.76 (95% CI: 0.63, 0.93) for EPA + DPA + DHA. Significant associations for ALA and n-6 PUFA with short sleep duration or difficulty falling asleep were not identified. Participants with higher concentrations of very long-chain n-3 PUFAs were less likely to have long sleep duration. While objective biomarkers reduce recall bias and misclassification, the cross-sectional design limits assessment of the temporal nature of this relation. These novel findings across 12 cohorts highlight the need for experimental and biological assessments of very long-chain n-3 PUFAs and sleep duration.
Editor: United States: Elsevier Inc
Idioma: Inglês

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PUFA ω-3 and ω-6 biomarkers and sleep: a pooled analysis of cohort studies on behalf of the Fatty Acids and Outcomes Research Consortium (FORCE)

United States: Elsevier Inc

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