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DNA origami nano-mechanics

Ji, Jiahao ; Karna, Deepak ; Mao, Hanbin

Chemical Society reviews, 2021-11, Vol.5 (21), p.11966-11978 [Periódico revisado por pares]

England: Royal Society of Chemistry

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  • Título:
    DNA origami nano-mechanics
  • Autor: Ji, Jiahao ; Karna, Deepak ; Mao, Hanbin
  • Assuntos: Biomechanics ; Disintegration ; DNA ; Elasticity ; Flexibility ; Mechanical properties ; Nanomaterials ; Nanostructures ; Nanotechnology devices ; Nucleic Acid Conformation ; Physiochemistry ; Plastic properties ; Topology
  • É parte de: Chemical Society reviews, 2021-11, Vol.5 (21), p.11966-11978
  • Notas: Deepak is currently a PhD candidate in the Department of Chemistry & Biochemistry, Kent State University, under the supervision of Prof. Hanbin Mao. He obtained his undergraduate degree in Biotechnology from Kathmandu University, Nepal. His major research interest lies in bionanotechnology targeted with DNA origamis.
    Jiahao Ji obtained his BS degree from School of Chemistry and Chemical Engineering, Nanjing University. Currently, he is a graduate student in Prof. Hanbin Mao's research group at the Department of Chemistry and Biochemistry, Kent State University, focusing on single-molecule mechanochemical studies.
    Professor Hanbin Mao got his PhD training in Analytical Chemistry at Texas A&M University in 2003. After two years of postdoctoral research at UC Berkeley specializing in single-molecule force spectroscopy, Dr Mao joined the Department of Chemistry and Biochemistry at Kent State University in 2005. His research is focused on biosensing and single molecular biophysics. His research lab in Kent State has developed a new interdisciplinary field, mechano-analytical chemistry, in which mechanical properties of molecules have been exploited for (bio)chemical analyses and mechanochemistry studies.
  • Descrição: Invention of DNA origami has transformed the fabrication and application of biological nanomaterials. In this review, we discuss DNA origami nanoassemblies according to their four fundamental mechanical properties in response to external forces: elasticity, pliability, plasticity and stability. While elasticity and pliability refer to reversible changes in structures and associated properties, plasticity shows irreversible variation in topologies. The irreversible property is also inherent in the disintegration of DNA nanoassemblies, which is manifested by its mechanical stability. Disparate DNA origami devices in the past decade have exploited the mechanical regimes of pliability, elasticity, and plasticity, among which plasticity has shown its dominating potential in biomechanical and physiochemical applications. On the other hand, the mechanical stability of the DNA origami has been used to understand the mechanics of the assembly and disassembly of DNA nano-devices. At the end of this review, we discuss the challenges and future development of DNA origami nanoassemblies, again, from these fundamental mechanical perspectives. We re-examine DNA origami nanoassemblies from four fundamental mechanical aspects of elasticity, pliability, plasticity and stability.
  • Editor: England: Royal Society of Chemistry
  • Idioma: Inglês
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