Idioma:

KIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

Li, Jing ; Zaslavsky, Maxim ; Su, Yapeng ; Guo, Jing ; Sikora, Michael J ; van Unen, Vincent ; Christophersen, Asbjørn ; Chiou, Shin-Heng ; Chen, Liang ; Li, Jiefu ; Ji, Xuhuai ; Wilhelmy, Julie ; McSween, Alana M ; Palanski, Brad A ; Mallajosyula, Venkata Vamsee Aditya ; Bracey, Nathan A ; Dhondalay, Gopal Krishna R ; Bhamidipati, Kartik ; Pai, Joy ; Kipp, Lucas B ; Dunn, Jeffrey E ; Hauser, Stephen L ; Oksenberg, Jorge R ; Satpathy, Ansuman T ; Robinson, William H ; Dekker, Cornelia L ; Steinmetz, Lars M ; Khosla, Chaitan ; Utz, Paul J ; Sollid, Ludvig M ; Chien, Yueh-Hsiu ; Heath, James R ; Fernandez-Becker, Nielsen Q ; Nadeau, Kari C ; Saligrama, Naresha ; Davis, Mark M

Science (American Association for the Advancement of Science), 2022-04, Vol.376 (6590), p.eabi9591-eabi9591 [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

Texto completo disponível

Citações Citado por

Enviar para

Título:
KIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19
Autor: Li, Jing ; Zaslavsky, Maxim ; Su, Yapeng ; Guo, Jing ; Sikora, Michael J ; van Unen, Vincent ; Christophersen, Asbjørn ; Chiou, Shin-Heng ; Chen, Liang ; Li, Jiefu ; Ji, Xuhuai ; Wilhelmy, Julie ; McSween, Alana M ; Palanski, Brad A ; Mallajosyula, Venkata Vamsee Aditya ; Bracey, Nathan A ; Dhondalay, Gopal Krishna R ; Bhamidipati, Kartik ; Pai, Joy ; Kipp, Lucas B ; Dunn, Jeffrey E ; Hauser, Stephen L ; Oksenberg, Jorge R ; Satpathy, Ansuman T ; Robinson, William H ; Dekker, Cornelia L ; Steinmetz, Lars M ; Khosla, Chaitan ; Utz, Paul J ; Sollid, Ludvig M ; Chien, Yueh-Hsiu ; Heath, James R ; Fernandez-Becker, Nielsen Q ; Nadeau, Kari C ; Saligrama, Naresha ; Davis, Mark M
Assuntos: Ablation ; Animals ; Autoimmune Diseases ; Autoimmunity ; CD4 antigen ; CD8 antigen ; CD8-Positive T-Lymphocytes ; Celiac disease ; Control Groups ; Coronaviruses ; COVID-19 ; Cytolytic activity ; Cytotoxicity ; Depletion ; Equivalence ; Experimental allergic encephalomyelitis ; Functionals ; Gene sequencing ; Gliadin ; Glycoproteins ; Humans ; Immunoglobulin-like receptors ; Immunoglobulins ; Immunological tolerance ; Immunology ; In vitro methods and tests ; Infections ; Infectious diseases ; Inflammation ; Influenza ; Killer cell immunoglobulin-like receptors ; Leukocytes ; Lymphocytes ; Lymphocytes T ; Major histocompatibility complex ; Mice ; Multiple sclerosis ; Myelin ; Negative feedback ; Patients ; Phenotypes ; Receptors ; Receptors, KIR ; Respiratory diseases ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Signs and symptoms ; T cell receptors ; T-Lymphocytes, Regulatory ; Toxicity ; Transcription ; Vasculitis ; Viral diseases ; Viral infections ; Viruses
É parte de: Science (American Association for the Advancement of Science), 2022-04, Vol.376 (6590), p.eabi9591-eabi9591
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
SKGJ/SKGJ-MED-017
Present address: Department of Medicine, Division of Genetics, Brigham and Women’s Hospital, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Present address: Immunology Graduate Program, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Present address: Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Present address: Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
Descrição: In this work, we find that CD8 T cells expressing inhibitory killer cell immunoglobulin-like receptors (KIRs) are the human equivalent of Ly49 CD8 regulatory T cells in mice and are increased in the blood and inflamed tissues of patients with a variety of autoimmune diseases. Moreover, these CD8 T cells efficiently eliminated pathogenic gliadin-specific CD4 T cells from the leukocytes of celiac disease patients in vitro. We also find elevated levels of KIR CD8 T cells, but not CD4 regulatory T cells, in COVID-19 patients, correlating with disease severity and vasculitis. Selective ablation of Ly49 CD8 T cells in virus-infected mice led to autoimmunity after infection. Our results indicate that in both species, these regulatory CD8 T cells act specifically to suppress pathogenic T cells in autoimmune and infectious diseases.
Editor: United States: The American Association for the Advancement of Science
Idioma: Inglês;Norueguês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

KIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

United States: The American Association for the Advancement of Science

Buscando em bases de dados remotas. Favor aguardar.