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Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7

Davies, Nicholas G ; Jarvis, Christopher I ; Edmunds, W John ; Jewell, Nicholas P ; Diaz-Ordaz, Karla ; Keogh, Ruth H

Nature (London), 2021-05, Vol.593 (7858), p.270-274 [Revista revisada por pares]

England: Nature Publishing Group

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Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7
Autor: Davies, Nicholas G ; Jarvis, Christopher I ; Edmunds, W John ; Jewell, Nicholas P ; Diaz-Ordaz, Karla ; Keogh, Ruth H
Materias: Adolescent ; Adult ; Age groups ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Confidence intervals ; Coronaviruses ; COVID-19 ; COVID-19 - mortality ; COVID-19 - virology ; Death ; Deprivation ; England - epidemiology ; Ethnicity ; Evolution, Molecular ; Fatalities ; Female ; Health hazards ; Homes for the Aged ; Humans ; Infant ; Laboratories ; Local government ; Male ; Middle Aged ; Minority & ethnic groups ; Mortality ; Mutation ; Nursing homes ; Phylogeny ; Proportional Hazards Models ; Risk Assessment ; S gene ; SARS-CoV-2 - classification ; SARS-CoV-2 - genetics ; SARS-CoV-2 - isolation & purification ; SARS-CoV-2 - pathogenicity ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Survival Analysis ; Time Factors ; Viral diseases ; Young Adult
Es parte de: Nature (London), 2021-05, Vol.593 (7858), p.270-274
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Author contributions N.G.D., C.I.J., K.D.-O. and R.H.K. performed analyses; all authors designed the study and wrote the manuscript.
Descripción: SARS-CoV-2 lineage B.1.1.7, a variant that was first detected in the UK in September 2020 , has spread to multiple countries worldwide. Several studies have established that B.1.1.7 is more transmissible than pre-existing variants, but have not identified whether it leads to any change in disease severity . Here we analyse a dataset that links 2,245,263 positive SARS-CoV-2 community tests and 17,452 deaths associated with COVID-19 in England from 1 November 2020 to 14 February 2021. For 1,146,534 (51%) of these tests, the presence or absence of B.1.1.7 can be identified because mutations in this lineage prevent PCR amplification of the spike (S) gene target (known as S gene target failure (SGTF) ). On the basis of 4,945 deaths with known SGTF status, we estimate that the hazard of death associated with SGTF is 55% (95% confidence interval, 39-72%) higher than in cases without SGTF after adjustment for age, sex, ethnicity, deprivation, residence in a care home, the local authority of residence and test date. This corresponds to the absolute risk of death for a 55-69-year-old man increasing from 0.6% to 0.9% (95% confidence interval, 0.8-1.0%) within 28 days of a positive test in the community. Correcting for misclassification of SGTF and missingness in SGTF status, we estimate that the hazard of death associated with B.1.1.7 is 61% (42-82%) higher than with pre-existing variants. Our analysis suggests that B.1.1.7 is not only more transmissible than pre-existing SARS-CoV-2 variants, but may also cause more severe illness.
Editor: England: Nature Publishing Group
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Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7

Davies, Nicholas G ; Jarvis, Christopher I ; Edmunds, W John ; Jewell, Nicholas P ; Diaz-Ordaz, Karla ; Keogh, Ruth H

England: Nature Publishing Group

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