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Intestinal inflammation alters the antigen-specific immune response to a skin commensal

Merana, Geil R. ; Dwyer, Laura R. ; Dhariwala, Miqdad O. ; Weckel, Antonin ; Gonzalez, Jeanmarie R. ; Okoro, Joy N. ; Cohen, Jarish N. ; Tamaki, Courtney M. ; Han, Jungmin ; Tasoff, Preston ; Palacios-Calderon, Yasmin ; Ha, Connie W.Y. ; Lynch, Susan V. ; Segre, Julia A. ; Kong, Heidi H. ; Kattah, Michael G. ; Ma, Averil ; Scharschmidt, Tiffany C.

Cell reports (Cambridge), 2022-05, Vol.39 (9), p.110891-110891, Article 110891 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Intestinal inflammation alters the antigen-specific immune response to a skin commensal
  • Autor: Merana, Geil R. ; Dwyer, Laura R. ; Dhariwala, Miqdad O. ; Weckel, Antonin ; Gonzalez, Jeanmarie R. ; Okoro, Joy N. ; Cohen, Jarish N. ; Tamaki, Courtney M. ; Han, Jungmin ; Tasoff, Preston ; Palacios-Calderon, Yasmin ; Ha, Connie W.Y. ; Lynch, Susan V. ; Segre, Julia A. ; Kong, Heidi H. ; Kattah, Michael G. ; Ma, Averil ; Scharschmidt, Tiffany C.
  • Assuntos: Animals ; colitis ; Colitis - chemically induced ; commensal ; commensal-specific T cells ; gut-skin axis ; Immunity ; Inflammation ; intestinal immunity ; Mice ; regulatory T cells ; S. epidermidis ; Skin ; skin immunity ; skin microbiome ; Staphylococcus epidermidis ; T-Lymphocytes, Regulatory
  • É parte de: Cell reports (Cambridge), 2022-05, Vol.39 (9), p.110891-110891, Article 110891
  • Notas: AUTHOR CONTRIBUTIONS
    G.R.M. and T.C.S. designed the studies and wrote the manuscript. G.R.M. performed the experiments and analyzed the data. A.W., C.M.T., J.H., J.N.C., J.N.O., J.R.G., L.R.D., M.O.D., P.T., and Y.P.-C. assisted with experiments. A.M., C.W.Y.H., H.H.K., J.A.S., M.G.K., and S.V.L. provided resources and input on experimental design. T.C.S. oversaw all study design and data analysis. All authors discussed results and commented on the manuscript.
  • Descrição: Resident microbes in skin and gut predominantly impact local immune cell function during homeostasis. However, colitis-associated neutrophilic skin disorders suggest possible breakdown of this compartmentalization with disease. Using a model wherein neonatal skin colonization by Staphylococcus epidermidis facilitates generation of commensal-specific tolerance and CD4+ regulatory T cells (Tregs), we ask whether this response is perturbed by gut inflammation. Chemically induced colitis is accompanied by intestinal expansion of S. epidermidis and reduces gut-draining lymph node (dLN) commensal-specific Tregs. It also results in reduced commensal-specific Tregs in skin and skin-dLNs and increased skin neutrophils. Increased CD4+ circulation between gut and skin dLN suggests that the altered cutaneous response is initiated in the colon, and resistance to colitis-induced effects in Cd4creIl1r1fl/fl mice implicate interleukin (IL)-1 in mediating the altered commensal-specific response. These findings provide mechanistic insight into observed connections between inflammatory skin and intestinal diseases. [Display omitted] •Intestinal inflammation undermines established tolerance to skin commensal bacteria•Murine models of colitis reverse the Treg-rich CD4+ response to S. epidermidis (S. epi)•Colitis promotes CD4+ T cell circulation between gut and skin-draining lymph nodes•T cell sensing of IL-1 shifts towards colitis-induced S. epi-specific effector T cells Merana et al. show that intestinal inflammation in adult mice undermines previously established immune tolerance to skin commensal bacteria, specifically leading to increased skin neutrophils and reduced percentages of S. epidermidis-specific regulatory T cells (Tregs) in the skin and in skin-draining lymph nodes.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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