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How expensive is the astrocyte?

Barros, LF

Journal of cerebral blood flow and metabolism, 2022-05, Vol.42 (5), p.738-745 [Periódico revisado por pares]

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Título:
How expensive is the astrocyte?
Autor: Barros, LF
Assuntos: Astrocytes - metabolism ; Brain Diseases ; Brief Opinion ; Humans ; Neuroglia ; Neurons - metabolism ; Sodium - metabolism
É parte de: Journal of cerebral blood flow and metabolism, 2022-05, Vol.42 (5), p.738-745
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The energy cost of information processing is thought to be chiefly neuronal, with a minor fraction attributed to glial cells. However, there is compelling evidence that astrocytes capture synaptic K+ using their Na+/K+ ATPase, and not solely through Kir4.1 channels as was once thought. When this active buffering is taken into account, the cost of astrocytes rises by >200%. Gram-per-gram, astrocytes turn out to be as expensive as neurons. This conclusion is supported by 3D reconstruction of the neuropil showing similar mitochondrial densities in neurons and astrocytes, by cell-specific transcriptomics and proteomics, and by the rates of the tricarboxylic acid cycle. Possible consequences for reactive astrogliosis and brain disease are discussed.
Editor: London, England: SAGE Publications
Idioma: Inglês

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