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Early developmental impact of sex chromosome trisomies on attention deficit‐hyperactivity disorder symptomology in young children

Kuiper, Kimberly ; Swaab, Hanna ; Tartaglia, Nicole ; Rijn, Sophie

American journal of medical genetics. Part A, 2021-12, Vol.185 (12), p.3664-3674 [Periódico revisado por pares]

Hoboken, USA: John Wiley & Sons, Inc

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Título:
Early developmental impact of sex chromosome trisomies on attention deficit‐hyperactivity disorder symptomology in young children
Autor: Kuiper, Kimberly ; Swaab, Hanna ; Tartaglia, Nicole ; Rijn, Sophie
Assuntos: Abnormal Karyotype ; ADHD ; Attention Deficit Disorder with Hyperactivity - diagnosis ; Attention Deficit Disorder with Hyperactivity - genetics ; Attention Deficit Disorder with Hyperactivity - physiopathology ; Attention deficit hyperactivity disorder ; Child ; Child, Preschool ; Children ; Cognition Disorders - diagnosis ; Cognition Disorders - genetics ; Cognition Disorders - physiopathology ; developmental psychopathology ; Female ; Humans ; Hyperactivity ; Impulsive behavior ; Infant ; Karyotypes ; Klinefelter syndrome ; Male ; Original ; Population genetics ; Psychopathology ; Regular ; Sex Chromosome Aberrations ; Sex chromosomes ; Sex Chromosomes - genetics ; Trisomy - genetics ; trisomy X syndrome ; XYY Karyotype - genetics
É parte de: American journal of medical genetics. Part A, 2021-12, Vol.185 (12), p.3664-3674
Notas: Funding information
National Institutes of Health, Grant/Award Number: UL1 TR002535; Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Grant/Award Number: 016.165.397
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Funding information National Institutes of Health, Grant/Award Number: UL1 TR002535; Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Grant/Award Number: 016.165.397
Descrição: Individuals with sex chromosome trisomies ([SCT], XXX, XXY, and XYY)) are at increased risk for neurodevelopmental problems, given that a significant portion of the sex chromosome genes impact brain functioning. An elevated risk for psychopathology has also been described, including attention deficit‐hyperactivity disorder (ADHD). The present study aimed at identifying early markers of ADHD, providing the first investigation of ADHD symptomology in very young children with SCT. The variety, type, and severity of ADHD symptomology in 1–6‐year‐old children with SCT (n = 104) were compared with population‐based controls (n = 101) using the strengths and weaknesses of ADHD symptoms and normal‐behavior (SWAN) parent‐report questionnaire. ADHD symptomology was significantly more prevalent in SCT and already present from toddlerhood on, compared to controls. ADHD inattention symptoms were significantly increased in all karyotypes (XXX, XXY, and XYY), boys with XYY also showed significantly more hyperactivity/impulsivity symptoms than controls. Inattentiveness was more pronounced with increasing age for SCT, in contrast to controls. Within the SCT group, 24% of the children had significantly elevated ADHD symptoms at a clinical level. Already from an early age on, SCT is associated with a risk for ADHD, suggesting that its neurodevelopmental risk lies anchored in early brain maturation. Studying this genetically vulnerable population allows for the prospective study of risk markers to facilitate early and preventive interventions.
Editor: Hoboken, USA: John Wiley & Sons, Inc
Idioma: Inglês

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Early developmental impact of sex chromosome trisomies on attention deficit‐hyperactivity disorder symptomology in young children

Kuiper, Kimberly ; Swaab, Hanna ; Tartaglia, Nicole ; Rijn, Sophie

Hoboken, USA: John Wiley & Sons, Inc

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