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Spray-dried chitosan microspheres cross-linked with d, l-glyceraldehyde as a potential drug delivery system: preparation and characterization

Oliveira, B. F ; Santana, M. H. A. ; Ré, M. I.

Brazilian journal of chemical engineering, 2005-09, Vol.22 (3), p.353-360 [Periódico revisado por pares]

Brazilian Society of Chemical Engineering

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  • Título:
    Spray-dried chitosan microspheres cross-linked with d, l-glyceraldehyde as a potential drug delivery system: preparation and characterization
  • Autor: Oliveira, B. F ; Santana, M. H. A. ; Ré, M. I.
  • Assuntos: ENGINEERING, CHEMICAL
  • É parte de: Brazilian journal of chemical engineering, 2005-09, Vol.22 (3), p.353-360
  • Descrição: Chitosan microspheres of a small particle size and with good sphericity were prepared by a spray-drying method followed by treatment with a cross-linking agent. Owing to restrictions on the use of cross-linked chitosan microspheres in the pharmaceutical field, d,l-glyceraldehyde, a biocompatible reatant was used. The parameters studied affecting extent of cross-linking were cross-linking time and concentration of the cross-linking agent. Glutaraldehyde, the aldehyde most frequently employed as chemical cross-linking agent for proteins, was also used as a control. The cross-linked spray-dried chitosan microspheres were analyzed with respect to their morphological aspects, particle size, zeta potential and water uptake capacity. It was found that an increase either in d,l-glyceraldehyde concentration or in duration of cross-linking caused a decrease in both the swelling capacity and the zeta potential of the chitosan microspheres. Compared to glutaraldehyde, d,l-glyceraldehyde appears to be a good cross-linking agent for chitosan microspheres with the advantage that it is nontoxic.
  • Editor: Brazilian Society of Chemical Engineering
  • Idioma: Inglês;Português
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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