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Study of pandrug and heavy metal resistance among E. coli from anthropogenically influenced Delhi stretch of river Yamuna

Azam, Mudsser ; Jan, Arif Tasleem ; Kumar, Ashutosh ; Siddiqui, Kehkashan ; Mondal, Aftab Hossain ; Haq, Qazi Mohd. Rizwanul

Brazilian journal of microbiology, 2018-07, Vol.49 (3), p.471-480 [Periódico revisado por pares]

Brazil: Elsevier Editora Ltda

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Título:
Study of pandrug and heavy metal resistance among E. coli from anthropogenically influenced Delhi stretch of river Yamuna
Autor: Azam, Mudsser ; Jan, Arif Tasleem ; Kumar, Ashutosh ; Siddiqui, Kehkashan ; Mondal, Aftab Hossain ; Haq, Qazi Mohd. Rizwanul
Assuntos: Adaptability ; Amoxicillin ; Anthropogenic factors ; Antibiotic resistance ; Antibiotics ; Antimicrobial agents ; Aztreonam ; Carbenicillin ; Cefotaxime ; Ceftazidime ; Clustering ; Combinatorial analysis ; Conjugation ; E coli ; Environmental Microbiology ; ESBLs ; Gene expression ; Genes ; Heavy metal resistance ; Heavy metals ; Localization ; Mercuric chloride ; Mercury compounds ; Metal concentrations ; MICROBIOLOGY ; Minimum inhibitory concentration ; Polluted environment ; Resistance factors ; Resistance genes ; Risk analysis ; Risk factors ; Rivers ; Tobramycin ; Water pollution
É parte de: Brazilian journal of microbiology, 2018-07, Vol.49 (3), p.471-480
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Authors contributed equally to this work.
Descrição: Escalating burden of antibiotic resistance that has reached new heights present a grave concern to mankind. As the problem is no longer confined to clinics, we hereby report identification of a pandrug resistant Escherichia coli isolate from heavily polluted Delhi stretch of river Yamuna, India. E. coli MRC11 was found sensitive only to tobramycin against 21 antibiotics tested, with minimum inhibitory concentration values >256μg/mL for amoxicillin, carbenicillin, aztreonam, ceftazidime and cefotaxime. Addition of certain heavy metals at higher concentrations were ineffective in increasing susceptibility of E. coli MRC11 to antibiotics. Withstanding sub-optimal concentration of cefotaxime (10μg/mL) and mercuric chloride (2μg/mL), and also resistance to their combinatorial use, indicates better adaptability in heavily polluted environment through clustering and expression of resistance genes. Interestingly, E. coli MRC11 harbours two different variants of blaTEM (blaTEM-116 and blaTEM-1 with and without extended-spectrum activity, respectively), in addition to mer operon (merB, merP and merT) genes. Studies employing conjugation, confirmed localization of blaTEM-116, merP and merT genes on the conjugative plasmid. Understanding potentialities of such isolates will help in determining risk factors attributing pandrug resistance and strengthening strategic development of new and effective antimicrobial agents.
Editor: Brazil: Elsevier Editora Ltda
Idioma: Inglês;Português

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Study of pandrug and heavy metal resistance among E. coli from anthropogenically influenced Delhi stretch of river Yamuna

Azam, Mudsser ; Jan, Arif Tasleem ; Kumar, Ashutosh ; Siddiqui, Kehkashan ; Mondal, Aftab Hossain ; Haq, Qazi Mohd. Rizwanul

Brazil: Elsevier Editora Ltda

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