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Transcription Factor Activating Protein-2β (TFAP-2β) genotype and symptoms of attention deficit hyperactivity disorder in relation to symptoms of depression in two independent samples

Nilsson, Kent W. ; Sonnby, Karin ; Nordquist, Niklas ; Comasco, Erika ; Leppert, Jerzy ; Oreland, Lars ; Sjöberg, Rickard L.

European child & adolescent psychiatry, 2014-04, Vol.23 (4), p.207-217 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
Transcription Factor Activating Protein-2β (TFAP-2β) genotype and symptoms of attention deficit hyperactivity disorder in relation to symptoms of depression in two independent samples
Autor: Nilsson, Kent W. ; Sonnby, Karin ; Nordquist, Niklas ; Comasco, Erika ; Leppert, Jerzy ; Oreland, Lars ; Sjöberg, Rickard L.
Assuntos: ADHD ; Adolescent ; Adolescents ; Adult and adolescent clinical studies ; Alleles ; Attention Deficit Disorder with Hyperactivity - diagnosis ; Attention Deficit Disorder with Hyperactivity - epidemiology ; Attention Deficit Disorder with Hyperactivity - genetics ; Attention deficit disorders. Hyperactivity ; attention deficit hyperactivity disorder ; Barn- och ungdomspsykiatri ; Biological and medical sciences ; Child and Adolescent Psychiatry ; Child and Youth Psychiatry ; Child clinical studies ; Comorbidity ; comorbitidy ; Depression ; Depression - diagnosis ; Depression - epidemiology ; Depression - genetics ; Depressive Disorder - diagnosis ; Depressive Disorder - epidemiology ; Depressive Disorder - genetics ; Female ; Gene-environment interaction ; Genotype ; Humans ; Longitudinal Studies ; Medical sciences ; Medicine ; Medicine & Public Health ; Minisatellite Repeats ; Mood disorders ; Original Contribution ; Polymorphism, Genetic - genetics ; Population Surveillance ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Sweden - epidemiology ; Transcription Factor AP-2 - genetics ; Transcription Factor AP-2 - metabolism ; Transcription factor AP-2 beta ; transcription factor AP-2β
É parte de: European child & adolescent psychiatry, 2014-04, Vol.23 (4), p.207-217
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The Transcription Factor Activating Protein - 2β ( TFAP - 2β ) gene has been shown to influence monoaminergic neurotransmission, and several genes important for monoaminergic function have binding sites for TFAP-2β. Familial studies of attention deficit hyperactivity disorder (ADHD) suggest a hereditary-determined subtype of ADHD with comorbid depression. We examined a functional variation of the TFAP - 2β gene in the context of co-occurring symptoms of ADHD and depression in two independent population-based samples of adolescents (Group A, n = 175 and Group B, n = 1,506) from Sweden. Results indicated 6.1 to 7.8 % of adolescents screened positively for ADHD and depression symptoms. Symptoms of depression were more common among girls who screened positively for ADHD and did not carry the nine-repeat allele of the TFAP - 2β intron 1 Variable Number Tandem Repeat (VNTR) polymorphism. The presence of the nine-repeat variant of the TFAP - 2β intron 1 VNTR appears to protect girls with ADHD symptoms from the co-expression of symptoms of depression.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês;Norueguês

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Transcription Factor Activating Protein-2β (TFAP-2β) genotype and symptoms of attention deficit hyperactivity disorder in relation to symptoms of depression in two independent samples

Nilsson, Kent W. ; Sonnby, Karin ; Nordquist, Niklas ; Comasco, Erika ; Leppert, Jerzy ; Oreland, Lars ; Sjöberg, Rickard L.

Berlin/Heidelberg: Springer Berlin Heidelberg

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