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The Hyperglycemia and Adverse Pregnancy Outcome Study: Associations of GDM and obesity with pregnancy outcomes

CATALANO, Patrick M ; DAVID MCINTYRE, H ; PERSSON, Bengt ; HOD, Moshe ; OATS, Jeremy J. N ; KENNEDY CRUICKSHANK, J ; MCCANCE, David R ; DYER, Alan R ; METZGER, Boyd E ; LOWE, Lynn P ; TRIMBLE, Elisabeth R ; COUSTAN, Donald R ; HADDEN, David R

Diabetes care, 2012-04, Vol.35 (4), p.780-786 [Periódico revisado por pares]

Alexandria, VA: American Diabetes Association

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Título:
The Hyperglycemia and Adverse Pregnancy Outcome Study: Associations of GDM and obesity with pregnancy outcomes
Autor: CATALANO, Patrick M ; DAVID MCINTYRE, H ; PERSSON, Bengt ; HOD, Moshe ; OATS, Jeremy J. N ; KENNEDY CRUICKSHANK, J ; MCCANCE, David R ; DYER, Alan R ; METZGER, Boyd E ; LOWE, Lynn P ; TRIMBLE, Elisabeth R ; COUSTAN, Donald R ; HADDEN, David R
Assuntos: Adult ; Biological and medical sciences ; Birth Weight - physiology ; Blood Glucose - analysis ; Blood Glucose - metabolism ; Body Mass Index ; Complications and side effects ; Diabetes ; Diabetes in pregnancy ; Diabetes, Gestational - blood ; Diabetes, Gestational - epidemiology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Glucose Tolerance Test ; Humans ; Hyperglycemia ; Hyperglycemia - blood ; Hyperglycemia - complications ; Hyperglycemia - epidemiology ; Infant, Newborn ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Metabolic diseases ; Miscellaneous ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Obstetric Labor Complications - blood ; Obstetric Labor Complications - epidemiology ; Obstetric Labor Complications - etiology ; Original Research ; Pregnancy ; Pregnancy Complications - blood ; Pregnancy Complications - epidemiology ; Pregnancy Complications - etiology ; Pregnancy Outcome - epidemiology ; Pregnancy, Complications of ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk factors ; Womens health ; Young Adult
É parte de: Diabetes care, 2012-04, Vol.35 (4), p.780-786
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: To determine associations of gestational diabetes mellitus (GDM) and obesity with adverse pregnancy outcomes in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. Participants underwent a 75-g oral glucose tolerance test (OGTT) between 24 and 32 weeks. GDM was diagnosed post hoc using International Association of Diabetes and Pregnancy Study Groups criteria. Neonatal anthropometrics and cord serum C-peptide were measured. Adverse pregnancy outcomes included birth weight, newborn percent body fat, and cord C-peptide >90th percentiles, primary cesarean delivery, preeclampsia, and shoulder dystocia/birth injury. BMI was determined at the OGTT. Multiple logistic regression was used to examine associations of GDM and obesity with outcomes. Mean maternal BMI was 27.7, 13.7% were obese (BMI ≥33.0 kg/m(2)), and GDM was diagnosed in 16.1%. Relative to non-GDM and nonobese women, odds ratio for birth weight >90th percentile for GDM alone was 2.19 (1.93-2.47), for obesity alone 1.73 (1.50-2.00), and for both GDM and obesity 3.62 (3.04-4.32). Results for primary cesarean delivery and preeclampsia and for cord C-peptide and newborn percent body fat >90th percentiles were similar. Odds for birth weight >90th percentile were progressively greater with both higher OGTT glucose and higher maternal BMI. There was a 339-g difference in birth weight for babies of obese GDM women, compared with babies of normal/underweight women (64.2% of all women) with normal glucose based on a composite OGTT measure of fasting plasma glucose and 1- and 2-h plasma glucose values (61.8% of all women). Both maternal GDM and obesity are independently associated with adverse pregnancy outcomes. Their combination has a greater impact than either one alone.
Editor: Alexandria, VA: American Diabetes Association
Idioma: Inglês

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The Hyperglycemia and Adverse Pregnancy Outcome Study: Associations of GDM and obesity with pregnancy outcomes

CATALANO, Patrick M ; DAVID MCINTYRE, H ; PERSSON, Bengt ; HOD, Moshe ; OATS, Jeremy J. N ; KENNEDY CRUICKSHANK, J ; MCCANCE, David R ; DYER, Alan R ; METZGER, Boyd E ; LOWE, Lynn P ; TRIMBLE, Elisabeth R ; COUSTAN, Donald R ; HADDEN, David R

Alexandria, VA: American Diabetes Association

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