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Oxidative Stress in Diabetic Peripheral Neuropathy: Pathway and Mechanism-Based Treatment

Lin, Qingxia ; Li, Kezheng ; Chen, Yinuo ; Xie, Jiali ; Wu, Chunxue ; Cui, Can ; Deng, Binbin

Molecular neurobiology, 2023-08, Vol.60 (8), p.4574-4594 [Periódico revisado por pares]

New York: Springer US

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Título:
Oxidative Stress in Diabetic Peripheral Neuropathy: Pathway and Mechanism-Based Treatment
Autor: Lin, Qingxia ; Li, Kezheng ; Chen, Yinuo ; Xie, Jiali ; Wu, Chunxue ; Cui, Can ; Deng, Binbin
Assuntos: Advanced glycosylation end products ; Antioxidants ; Antioxidants - metabolism ; Antioxidants - therapeutic use ; Bioavailability ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Diabetes ; Diabetes Mellitus ; Diabetic Neuropathies - drug therapy ; Drug delivery ; Glycation End Products, Advanced - metabolism ; Glycolysis ; Glycosylation ; Humans ; Kinases ; Medicin och hälsovetenskap ; Neurobiology ; Neurology ; Neurosciences ; Non-coding RNA ; Oxidation ; Oxidative stress ; Oxidative Stress - physiology ; Peripheral neuropathy ; Protein kinase C ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Rehabilitation
É parte de: Molecular neurobiology, 2023-08, Vol.60 (8), p.4574-4594
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
Descrição: Diabetic peripheral neuropathy (DPN) is a major complication of diabetes mellitus with a high incidence. Oxidative stress, which is a crucial pathophysiological pathway of DPN, has attracted much attention. The distortion in the redox balance due to the overproduction of reactive oxygen species (ROS) and the deregulation of antioxidant defense systems promotes oxidative damage in DPN. Therefore, we have focused on the role of oxidative stress in the pathogenesis of DPN and elucidated its interaction with other physiological pathways, such as the glycolytic pathway, polyol pathway, advanced glycosylation end products, protein kinase C pathway, inflammation, and non-coding RNAs. These interactions provide novel therapeutic options targeting oxidative stress for DPN. Furthermore, our review addresses the latest therapeutic strategies targeting oxidative stress for the rehabilitation of DPN. Antioxidant supplements and exercise have been proposed as fundamental therapeutic strategies for diabetic patients through ROS-mediated mechanisms. In addition, several novel drug delivery systems can improve the bioavailability of antioxidants and the efficacy of DPN.
Editor: New York: Springer US
Idioma: Inglês

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Oxidative Stress in Diabetic Peripheral Neuropathy: Pathway and Mechanism-Based Treatment

Lin, Qingxia ; Li, Kezheng ; Chen, Yinuo ; Xie, Jiali ; Wu, Chunxue ; Cui, Can ; Deng, Binbin

New York: Springer US

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