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Brain‐derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease

Pineda, José R. ; Canals, Josep M ; Bosch, Miquel ; Adell, Albert ; Mengod, Guadalupe ; Artigas, Francesc ; Ernfors, Patrik ; Alberch, Jordi

Journal of neurochemistry, 2005-06, Vol.93 (5), p.1057-1068 [Periódico revisado por pares]

Oxford, UK: Blackwell Science Ltd

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Título:
Brain‐derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease
Autor: Pineda, José R. ; Canals, Josep M ; Bosch, Miquel ; Adell, Albert ; Mengod, Guadalupe ; Artigas, Francesc ; Ernfors, Patrik ; Alberch, Jordi
Assuntos: amphetamine ; Amphetamine - pharmacology ; Animals ; Axonal Transport ; Biological and medical sciences ; Brain-Derived Neurotrophic Factor - genetics ; Brain-Derived Neurotrophic Factor - metabolism ; Corpus Striatum - metabolism ; Corpus Striatum - physiopathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dopamine - metabolism ; Dopamine Agents - pharmacology ; Huntington Disease - physiopathology ; Medical sciences ; Medicin och hälsovetenskap ; Mice ; Mice, Transgenic ; Motor ability ; Motor Activity - drug effects ; movement disorders ; Mutation ; Nerve Tissue Proteins - genetics ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neurological disorders ; Neurology ; neuronal dysfunction ; Neurons - metabolism ; Neurons - pathology ; neurotrophins ; Nuclear Proteins - genetics ; Receptors, Dopamine D1 - genetics ; Receptors, Dopamine D2 - genetics ; RNA, Messenger - metabolism ; Rodents ; substantia nigra ; Substantia Nigra - metabolism ; Substantia Nigra - pathology ; Substantia Nigra - physiopathology ; Transgenic animals
É parte de: Journal of neurochemistry, 2005-06, Vol.93 (5), p.1057-1068
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SourceType-Scholarly Journals-1
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Descrição: Dysfunction of dopaminergic neurons may contribute to motor impairment in Huntington's disease. Here, we study the role of brain‐derived neurotrophic factor (BDNF) in alterations of the nigrostriatal system associated with transgenics carrying mutant huntingtin. Using huntingtin‐BDNF+/– double‐mutant mice, we analyzed the effects of reducing the levels of BDNF expression in a model of Huntington's disease (R6/1). When compared with R6/1 mice, these mice exhibit an increased number of aggregates in the substantia nigra pars compacta. In addition, reduction of BDNF expression exacerbates the dopaminergic neuronal dysfunction seen in mutant huntingtin mice, such as the decrease in retrograde labelling of dopaminergic neurons and striatal dopamine content. However, mutant huntingtin mice with normal or lowered BDNF expression show the same decrease in the anterograde transport, number of dopaminergic neurons and nigral volume. In addition, reduced BDNF expression causes decreased dopamine receptor expression in mutant huntingtin mice. Examination of changes in locomotor activity induced by dopamine receptor agonists revealed that, in comparison with R6/1 mice, the double mutant mice exhibit lower activity in response to amphetamine, but not to apomorphine. In conclusion, these findings demonstrate that the decreased BDNF expression observed in Huntington's disease exacerbates dopaminergic neuronal dysfunction, which may participate in the motor disturbances associated with this neurodegenerative disorder.
Editor: Oxford, UK: Blackwell Science Ltd
Idioma: Inglês

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Brain‐derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease

Pineda, José R. ; Canals, Josep M ; Bosch, Miquel ; Adell, Albert ; Mengod, Guadalupe ; Artigas, Francesc ; Ernfors, Patrik ; Alberch, Jordi

Oxford, UK: Blackwell Science Ltd

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