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蜂胶对致癌物诱导金仓鼠舌黏膜反应的影响

Lopes-Rocha Ricardo Barroso Poliana Ribeiro Santos Alexandre Soares Lima Nadia Lages Ferreira Fernanda Oliveiraa Verli Flaviana Dornela

中西医结合学报, 2012, Vol.10 (12), p.1443-1450

Department of Dentistry,Federal University of Vales do Jequitinhonha e Mucuri,Diamantina,39100-000,Brazil%Department of Pharmacy,Federal University of Vales do Jequitinhonha e Mucuri,Diamantina,39100-000,Brazil%Department of Basic Sciences,Federal University of Vales do Jequitinhonha e Mucuri,Diamantina,39100-000,Brazil

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  • Título:
    蜂胶对致癌物诱导金仓鼠舌黏膜反应的影响
  • Autor: Lopes-Rocha Ricardo Barroso Poliana Ribeiro Santos Alexandre Soares Lima Nadia Lages Ferreira Fernanda Oliveiraa Verli Flaviana Dornela
  • Assuntos: 10-二甲基-1 ; 2-苯并葸 ; 9 ; 化学预防 ; 致癌性试验 ; 蜂胶 ; 金仓鼠
  • É parte de: 中西医结合学报, 2012, Vol.10 (12), p.1443-1450
  • Notas: Lopes-Rocha Ricardo, Barroso Poliana Ribeiro, Santos Alexandre Soares, Lima Nddia Lages , Ferreira Fernanda Oliveira , Verli Flaviana Dornela（1. Department of Dentistry, Federal University of Vales do Jequitinhonha e Mucuri, Diamantina, 39100-000, Brazil 2. Department Brazil 3. Department 000, Brazil of Pharmacy, Federal University of Vales do J equitinhonha e Mucuri, Diamantina, 39100-000, of Basic Sciences, Federal University of Vales do Jequitinhonha e Mucuri, Diamantina, 39100）
    31-1906/R
    propotis; carcinogenicity tests; 9, 10-dimethyl-1,2-benzanthracene; chemopre-vention ; Mesocricetus
    OBJECTIVE： To assess the tissue reaction of the lingual mucosa in hamsters submitted to daily, alternating, topical applications of 9,10-dimethyl-1,2-benzanthracene （DMBA） and a commercial brand of an ethanol propolis extract （EPE）. METHODS. A total of 60 hamsters were divided into three groups with two experimental periods （13 and 20 weeks）. The lateral edge of the tongue was submitted to daily, alternating, topical applicati
  • Descrição: 目的：研究9，10-二甲基-1，2-苯并蒽（9，10-dimethyl-1，2-benzanthracene，DMBA）以及蜂胶乙醇提取物（ethanol extract of propolis，EPE）对金仓鼠舌黏膜组织反应的影响。方法：60只金仓鼠按实验周期被随机分为两大组，每组再被分为EPE组、蜂胶水提取物（aqueous propolis extract，APE）组和DMBA组（n=20）。测定实验鼠舌黏膜的临床和组织学改变，包括面积、容积的临床改变，鳞状上皮组织的结构和细胞学变化，并测量鳞状细胞癌组织学上的改变区域。结果：各组在第13周和第20周所测定的实验结果不存在显著差异。在第13周，EPE组出现1例单-鳞状细胞癌；在第20周，EPE组的鳞状细胞癌的发生率最高，但与其他组比较差异无统计学意义。结论：蜂胶乙醇提取物对舌黏膜组织的影响以及其致癌机制还有待研究。
  • Editor: Department of Dentistry,Federal University of Vales do Jequitinhonha e Mucuri,Diamantina,39100-000,Brazil%Department of Pharmacy,Federal University of Vales do Jequitinhonha e Mucuri,Diamantina,39100-000,Brazil%Department of Basic Sciences,Federal University of Vales do Jequitinhonha e Mucuri,Diamantina,39100-000,Brazil
  • Idioma: Chinês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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