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Cryptic surface-associated multicellularity emerges through cell adhesion and its regulation

van Gestel, Jordi ; Wagner, Andreas

Public Library of Science (PLoS) 2021-05

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  • Título:
    Cryptic surface-associated multicellularity emerges through cell adhesion and its regulation
  • Autor: van Gestel, Jordi ; Wagner, Andreas
  • Assuntos: Animals (Zoology) ; biology ; General Agricultural and Biological Sciences, General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Neuroscience ; Institute of Evolutionary Biology and Environmental Studies ; Life sciences
  • Notas: van Gestel, Jordi; Wagner, Andreas (2021). Cryptic surface-associated multicellularity emerges through cell adhesion and its regulation. PLoS Biology, 19(5):e3001250.
    info:eu-repo/grantAgreement/SNSF/Projectfunding/31003A_172887/CH
    info:eu-repo/grantAgreement/SNSF/Projectfunding/P400PB_186789/CH
    info:eu-repo/grantAgreement/EC/H2020/742235
    https://www.zora.uzh.ch/id/eprint/212679/
    10.1371/journal.pbio.3001250
    info:eu-repo/grantAgreement/unknown/Wierenga Rengerink PhD Prize/
    info:eu-repo/grantAgreement/EC/H2020/739874
  • Descrição: The repeated evolution of multicellularity led to a wide diversity of organisms, many of which are sessile, including land plants, many fungi, and colonial animals. Sessile organisms adhere to a surface for most of their lives, where they grow and compete for space. Despite the prevalence of surface-associated multicellularity, little is known about its evolutionary origin. Here, we introduce a novel theoretical approach, based on spatial lineage tracking of cells, to study this origin. We show that multicellularity can rapidly evolve from two widespread cellular properties: cell adhesion and the regulatory control of adhesion. By evolving adhesion, cells attach to a surface, where they spontaneously give rise to primitive cell collectives that differ in size, life span, and mode of propagation. Selection in favor of large collectives increases the fraction of adhesive cells until a surface becomes fully occupied. Through kin recognition, collectives then evolve a central-peripheral polarity in cell adhesion that supports a division of labor between cells and profoundly impacts growth. Despite this spatial organization, nascent collectives remain cryptic, lack well-defined boundaries, and would require experimental lineage tracking technologies for their identification. Our results suggest that cryptic multicellularity could readily evolve and originate well before multicellular individuals become morphologically evident.
  • Editor: Public Library of Science (PLoS)
  • Data de criação/publicação: 2021-05
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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