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Patients with common variable immunodeficiency display a decrease in cell-surface activation markers and cytokines synthesis

Paolo Ruggero Errante Luiz Vicente Rizzo; G. V Baracho; M Toledo-Barros; C Kockron; Congresso Instituto Ciências Biomédicas, IV (2. 2003 São Paulo)

Resumos São Paulo: Comissão de Pesquisa do ICB/USP

São Paulo Comissão de Pesquisa do ICB/USP 2003

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  • Título:
    Patients with common variable immunodeficiency display a decrease in cell-surface activation markers and cytokines synthesis
  • Autor: Paolo Ruggero Errante
  • Luiz Vicente Rizzo; G. V Baracho; M Toledo-Barros; C Kockron; Congresso Instituto Ciências Biomédicas, IV (2. 2003 São Paulo)
  • Assuntos: IMUNOLOGIA
  • É parte de: Resumos São Paulo: Comissão de Pesquisa do ICB/USP
  • Notas: Disponível em CD-ROM
  • Descrição: AIM: Common variable immunodeficiency (CVID) is a heterogeneous group of immunologic disorders characterized by hypogammaglobulinemia and recurrent bacterial infections. This syndrome has been associated with different immunologic defects. Here we described the decrease in the expression of different activation markers and B and T interaction molecules in the cell surface of peripherical blood mononuclear cells (PBMC) from these patients. Material and Methods: Blood samples were collected from CVID patients and normal controls and the mononuclear cells were separated by gradient centrifugation. PBMC were cultured with phytohemaglutin A (PHA) during 24, 48, 72 and 96 hours. Cells were subject to flow cytometer analysis (FACS) for the expression of CD25, CD69, CD152 and CD70 in CD3+/CD4+. Supernatants were collected for quantitation of cytokines by ELISA. Results: We observed a most diminished expression of CD25, CD69 and CD70 in cell-surface of PBMC from CVID patients as well as lower cytokines synthesis (IL-4, IL-5 and IL-10) in supernatants than normal culture. Discussion: Our findings suggest that a decrease in different cell markers and impaired secretion of cytokines by T cells from CVID patients is a possible link between T cell deficiency and the impaired B cell function in CVID
  • Editor: São Paulo Comissão de Pesquisa do ICB/USP
  • Data de criação/publicação: 2003
  • Formato: Poster 122.
  • Idioma: Português
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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