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Evidence that B-1 cells participate via IL-10 secretion in the wound healing process in mice

H C Oliveira A F Popi; Mário Mariano; Meeting of the Brazilian Society for Immunology (31. 2006 Búzios)

Abstracts São Paulo, SP: Brazilian Society for Immunology, 2006

São Paulo 2006

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  • Título:
    Evidence that B-1 cells participate via IL-10 secretion in the wound healing process in mice
  • Autor: H C Oliveira
  • A F Popi; Mário Mariano; Meeting of the Brazilian Society for Immunology (31. 2006 Búzios)
  • Assuntos: IMUNOLOGIA
  • É parte de: Abstracts São Paulo, SP: Brazilian Society for Immunology, 2006
  • Notas: Disponível em CD-ROM
  • Descrição: Introduction and Objectives: Wound healing is a complex phenomenon whose mechanisms are not fully understood. This process is characterized by the proliferation, migration and cellular differentiation. Many cellular types are recruited to the site of the lesion. However, there are no reports concerning the participation of B lymphocytes in tissue repair. B-1 cells differ from conventional B cell by its anatomical location, ontogeny, surface markers expression, production of antibodies and growth properties. B-1 cells are present in the peritoneal and pleural cavities and rare in the spleen and absent in the lymph nodes of adult mice. It has been reported that these cells secret large amounts of IL-10. Almeida et al (Inter Immunol, 2001:13,1193) demonstrated that B-1 cells proliferate in stationary culture of adherent peritoneal cells. Further that B-1 cells migrate to a non-specific inflammatory focus and differentiate into a macrophage like-cell. It has been reported that BALB/Xid mice do not have B-1 cells in their peritoneal and pleural cavities. Using this model, we have previously demonstrated that B-1 cells participate in the wound healing process since BALB/Xid mice have a delayed wound healing kinetics as compared with BALB/c and BALB/Xid reconstituted with B-1 cells. Herein we report the possible participation of IL-10 in the phenomenon. Methods and Results: Standardized lesions were made in the dorsal region of the footpad
    of the animals and the kinetics of the inflammatory response evaluated by dial thickness gage. Results show that BALB/Xid have an increased inflammatory response as compared to BALB/c mice (n=8, p<0,01). C57/BL6 IL-10 KO mice had an increased inflammatory response when compared with C57/BL6 mice (n=9, p<0,001). However, the inflammatory response in C57/BL6 IL-10 KO mice reconstituted with a purified suspension of B-1 cells (1,5x106) had a similar inflammatory response as that observed in wild type mice. Conclusion: These data indicate that IL-10 secreted by B-1 cells participate of inflammatory response and confirm the participation of B-1 cells in the wound healing process.
  • Editor: São Paulo
  • Data de criação/publicação: 2006
  • Formato: res. CI.048.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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