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The number of immature phagocytes increases in the lymph node of Leishmania major-infected mice and their presence is related to IL-12P40 production

L P V Cardoso Ises de Almeida Abrahamsohn; P J M Leenen; Glória Maria Collet de Araujo Lima; M A P Oliveira; Meeting of the Brazilian Society for Immunology (31. 2006 Búzios)

Abstracts São Paulo, SP: Brazilian Society for Immunology, 2006

São Paulo 2006

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  • Title:
    The number of immature phagocytes increases in the lymph node of Leishmania major-infected mice and their presence is related to IL-12P40 production
  • Author: L P V Cardoso
  • Ises de Almeida Abrahamsohn; P J M Leenen; Glória Maria Collet de Araujo Lima; M A P Oliveira; Meeting of the Brazilian Society for Immunology (31. 2006 Búzios)
  • Subjects: IMUNOLOGIA
  • Is Part Of: Abstracts São Paulo, SP: Brazilian Society for Immunology, 2006
  • Notes: Disponível em CD-ROM
  • Description: Introduction and Objectives: Toxoplasma gondii is an obligate intracellular parasite responsible for more than two billion people infected worldwide. The Retinochoroiditis toxoplasmic is the most common uveitis posterior infection, include in Brazilian population. In the endemic region of Erechim (RS) about 88% of the population is soropositive and 18% have ocular lesions (OL). The diagnosis of toxoplasmosis can be extremely difficult. Humoral immune response against the parasite is effective, antibodies are used as diagnostic markers, and however, the role of their in resistance to T.gondii infection is controversial. The aim was investigate the correlation between antibody titers and clinical symptoms of toxoplasmic retinochoroiditis. Methods and Results: Specifics immunoglobulins anti-T. gondii were detected by ELISA developed in-house. 338 samples from patients were evaluated to IgG subclasses (indirect ELISA) and 200 samples were evaluated to IgA and IgE (antibody capture ELISA). The subjects were classified in different clinical groups, including soronegative, soropositive without OL for 2 years after serological diagnosis, recently infected individuals (IgM+) with or without OL and chronically infected individuals with severe or mild ocular lesions from Clinica Silveira in Erechim, RS, Brazil. Our data shown that IgG1 anti- T. gondii was detected in all groups analyzed. The isotypes IgA, IgE, IgG1 and IgG3 were
    predominant in patients IgM+. IgA was detected mainly in acutely infected patients between 41-50 years old. There were no statistical differences in the production of all IgG isotypes, on the basis of age group. There was no detection of IgG3 in patients chronically infected. Among the chronically infected individuals with ocular severe and mild lesion about 96% had IgG1, 25% IgG2, 26% IgG3 and less than 10% was detected IgG4 production. Conclusion: Our results suggest that T.gondii specific -IgG1 and -IgG3 were the most prevalent IgG subclasses found in serum from individuals with acute toxoplasmosis. We will follow up clinically and serologically these recently infected individuals for correlate the specific anti- T. gondii immunoglobulins production and ocular disease.
  • Publisher: São Paulo
  • Creation Date: 2006
  • Format: res. ID.184.
  • Language: English
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