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Receptor classification the integration of operational, structural, and transductional information

D. G Trist

New York, N.Y. New York Academy of Sciences 1997

Localização: FM - Fac. Medicina    (QU15 R244 1997 )(Acessar)

  • Título:
    Receptor classification the integration of operational, structural, and transductional information
  • Autor: D. G Trist
  • Assuntos: Neurotransmitter receptors -- Congresses; RECEPTORES DE NEUROTRANSMISSORES; RECEPTORES DE DROGA (CLASSIFICAÇÃO); Receptors, Cell Surface -- classification -- congresses; Receptors, Drug -- classification -- congresses
  • Notas: Includes bibliographical references and index
  • Descrição: Pt. 1. Principles and approaches -- The characterization and classification of neurotransmitter receptors -- Protein structures in receptor classification -- Transduction is a major factor influencing receptor characterization -- To what extent can binding studies allow the quantification of affinity and efficacy? -- Pt. 2. Current issues and challenges -- Criteria for the classification of hormone receptors with implications for nomenclature: an imp ossible task? -- Do recombinant receptor assays provide affinity and potency estimates? -- How receptor mutagenesis may confirm or confuse receptor nomenclature -- A genome-based receptor nomenclature -- Pt. 3. Influence of rec ent theoretical advances -- Do recent operational studies indicate that a single state model is no longer applicable to G-protein-coupled receptors? -- Agonist efficacy and allosteric models of receptor action -- Protean agonis ts: keys to receptor-active states? -- Is promiscuity of G-protein interaction an issue in the classification of receptors? -- Kinetic models of ion channels -- Pt. 4. Oral communication -- The classification of bioamine recept ors: how helpful are molecular phylogenies? -- Neurokinnin receptors: comparison of data from classical pharmacology, binding, and molecular biology -- The alpha and omega of G-protein-coupled receptors: a novel method for clas sification -- Evolutionary conservation of the 5-HT2beta receptors -- General discussion -- Poster presentations
  • Títulos relacionados: Série:Annals of the New York Academy of Sciences v. 812
  • Editor: New York, N.Y. New York Academy of Sciences
  • Data de criação/publicação: 1997
  • Formato: xii, 244 p. ill. 24 cm.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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