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Diagnosis of hantavirus infection in humans and rodents in Ribeirão Preto, State of São Paulo, Brazil

Glauciane Garcia de Figueiredo Alessandra Abel Borges; Gelse Mazzoni Campos; Alex Martins Machado; Fabiano Pinto Saggioro; Gilberto dos Santos Sabino Júnior; Soraya Jabur Badra; Alberto Anastacio Amarilla Ortiz; Luiz Tadeu Moraes Figueiredo

Revista da Sociedade Brasileira de Medicina Tropical Uberaba v. 43, n. 4, p. 348-354, 2010

Uberaba 2010

Available at FMRP - Fac. Medicina de Ribeirão Preto    (pcd 1965176 Estantes Deslizantes )(GetIt)

  • Title:
    Diagnosis of hantavirus infection in humans and rodents in Ribeirão Preto, State of São Paulo, Brazil
  • Author: Glauciane Garcia de Figueiredo
  • Alessandra Abel Borges; Gelse Mazzoni Campos; Alex Martins Machado; Fabiano Pinto Saggioro; Gilberto dos Santos Sabino Júnior; Soraya Jabur Badra; Alberto Anastacio Amarilla Ortiz; Luiz Tadeu Moraes Figueiredo
  • Subjects: INFECÇÕES POR HANTAVIRUS (DIAGNÓSTICO); ROEDORES (CONTAMINAÇÃO TRANSMISSÃO)
  • Is Part Of: Revista da Sociedade Brasileira de Medicina Tropical Uberaba v. 43, n. 4, p. 348-354, 2010
  • Description: Introduction: Hantavirus pulmonary and cardiovascular syndrome (HPCS) is an emerging serious disease in the Americas. Hantaviruses (Bunyaviridae) are the causative agents of this syndrome and are mainly transmitted through inhalation of aerosols containing the excreta of wild rodents. In the Ribeirão Preto region (state of São Paulo, Brazil), HPCS has been reported since 1998, caused by the Araraquara virus (ARAV), for which Necromys lasiurus is the rodent reservoir. This study aimed to show diagnostic results relating to infection in humans and rodents, obtained at the Virology Research Center of the Ribeirão Preto School of Medicine, University of São Paulo, between 2005 and 2008. Methods: HPCS was diagnosed by means of ELISA and/or RT-PCR in 11 (21.2%) out of 52 suspected cases, and 54.4% of these were fatal. Furthermore, 595 wild rodents (Necromys lasiurus, Akodon sp, Calomys tener and Oligoryzomys sp) were caught between 2005 and 2008. Results: Fifteen (2.5%) of these rodents presented antibodies for hantavirus, as follows: Necromys lasiurus (4%), Calomys tener (1.9%) and Akodon sp (1.5%). Nucleotide sequences obtained through RT-PCR from one HPCS patient and one Calomys tener rodent were compared with hantavirus sequences from GenBank, which showed that both were homologous with ARAV. Conclusions: This work corroborates previous studies showing that ARAV is the hantavirus causing HPCS in the Ribeirão Preto region. It also shows that rodents infected with hantavirus represent a constant risk of transmission of this virus to man
  • Publisher: Uberaba
  • Creation Date: 2010
  • Format: p. 348-354.
  • Language: English
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