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Factors associated with brain volume in major depression in older adults without dementia results from a large autopsy study

Paula Villela Nunes Claudia Kimie Suemoto; Renata Elaine Paraizo Leite; Renata Eloah de Lucena Ferretti-Rebustini; Carlos Augusto Gonçalves Pasqualucci; Ricardo Nitrini; José Marcelo Farfel; Kátia Cristina de Oliveira; Lea Tenenholz Grinberg; Nicole Rezende da Costa; Camila Fernandes Nascimento; Faraz Salmasi; Helena Kyunghee Kim; Lionel Trevor Young; Wilson Jacob Filho; Beny Lafer

International Journal of Geriatric Psychiatry v.1, p.[1]-7, Jan. 2017

Chichester 2017

Localização: EE - Escola de Enfermagem    (FERRETTI-REBUSTINI, R. E. de L. doc 52 ) e outros locais(Acessar)

  • Título:
    Factors associated with brain volume in major depression in older adults without dementia results from a large autopsy study
  • Autor: Paula Villela Nunes
  • Claudia Kimie Suemoto; Renata Elaine Paraizo Leite; Renata Eloah de Lucena Ferretti-Rebustini; Carlos Augusto Gonçalves Pasqualucci; Ricardo Nitrini; José Marcelo Farfel; Kátia Cristina de Oliveira; Lea Tenenholz Grinberg; Nicole Rezende da Costa; Camila Fernandes Nascimento; Faraz Salmasi; Helena Kyunghee Kim; Lionel Trevor Young; Wilson Jacob Filho; Beny Lafer
  • Assuntos: DEPRESSÃO; IDOSOS; HIPERTENSÃO; AUTÓPSIA; DIABETES MELLITUS
  • É parte de: International Journal of Geriatric Psychiatry v.1, p.[1]-7, Jan. 2017
  • Descrição: Objective: We examined brain volume and atrophy in individuals with major depressive disorder (MDD) without dementia that were referred to a large autopsy service. We also examined potential risk factors for brain atrophy, including demographics and clinical variables. Methods:In this study, 1373 participants (787 male) aged 50 years or older who died from natural causes were included. Participants with no reliable informant, with cognitive impairment or dementia, with a medical history of severe chronic disease, or with prolonged agonal state were excluded. Presence of MDD at least once in their lifetime was defined according to the Structured Clinical Interview for DSM. Brain volume was measured immediately after removal from the skull. Results: Mean age at death was 68.6 11.6, and MDD was present in 185 (14%) individuals. Smaller brain volume was associated with older age (p<0.001), lower education (years; p<0.001), hypertension (p= 0.001), diabetes (p= 0.006), and female gender (p<0.001). In the multivariate analysis adjusted for sociodemographics and cardiovascular risk factors, smaller brain volume was not associated with major depression (β=0.86, 95% CI =26.50 to 24.77, p= 0.95). Conclusions: In this large autopsy study of older adults, MDD was not associated with smaller brain volumes. Regardless of the presence of MDD, in this sample of older adults without dementia, we found that smaller brain volumes were associated with risk factors for brain neurodegeneration such as older age, diabetes, hypertension, and lower education
  • Editor: Chichester
  • Data de criação/publicação: 2017
  • Formato: p. [1]-7.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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