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Neuropathological correlates of neuropsychiatric symptoms in dementia

Lucy L Gibson Lea T Grinberg; Dominic ffytche; Renata E. P Leite; Roberta D Rodriguez; Renata Eloah de Lucena Ferretti-Rebustini; Carlos Augusto Gonçalves Pasqualucci; Ricardo Nitrini; Wilson Jacob Filho; Dag Aarsland; Claudia Kimie Suemoto

Alzheimer's & dementia: the journal of the Alzheimer's Association v. 19, p. 1372-1382, 2023

Orlando 2023

Acesso online. A biblioteca também possui exemplares impressos.

  • Título:
    Neuropathological correlates of neuropsychiatric symptoms in dementia
  • Autor: Lucy L Gibson
  • Lea T Grinberg; Dominic ffytche; Renata E. P Leite; Roberta D Rodriguez; Renata Eloah de Lucena Ferretti-Rebustini; Carlos Augusto Gonçalves Pasqualucci; Ricardo Nitrini; Wilson Jacob Filho; Dag Aarsland; Claudia Kimie Suemoto
  • Assuntos: SINTOMAS PSÍQUICOS; DOENÇAS NEURODEGENERATIVAS
  • É parte de: Alzheimer's & dementia: the journal of the Alzheimer's Association v. 19, p. 1372-1382, 2023
  • Notas: Disponível em: https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.12765. Acesso em: 26 abr. 2023
  • Descrição: Introduction Neuropsychiatric symptoms (NPS) are common in Lewy body disease (LBD), but their etiology is poorly understood. Methods In a population-based post mortem study neuropathological data was collected for Lewy body (LB) neuropathology, neurofibrillary tangles (NFT), amyloid beta burden, TDP-43, lacunar infarcts, cerebral amyloid angiopathy (CAA), and hyaline atherosclerosis. Post mortem interviews collected systematic information regarding NPS and cognitive status. A total of 1038 cases were included: no pathology (NP; n = 761), Alzheimer's disease (AD; n = 189), LBD (n = 60), and AD+LBD (n = 28). Results Hallucinations were associated with higher LB Braak stages, while higher NFT Braak staging was associated with depression, agitation, and greater number of symptoms in the Neuropsychiatric Inventory. Cases with dual AD+LBD pathology had the highest risk of hallucinations, agitation, apathy, and total symptoms but a multiplicative interaction between these pathologies was not significant. Discussion LB and AD pathology contribute differentially to NPS likely with an additive process contributing to the increased burden of NPS
  • Editor: Orlando
  • Data de criação/publicação: 2023
  • Formato: 1372-1382.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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