skip to main content
Visitante
Meu Espaço
Minha Conta
Sair
Identificação
This feature requires javascript
Tags
Revistas Eletrônicas (eJournals)
Livros Eletrônicos (eBooks)
Bases de Dados
Bibliotecas USP
Ajuda
Ajuda
Idioma:
Inglês
Espanhol
Português
This feature required javascript
This feature requires javascript
Primo Search
Busca Geral
Busca Geral
Acervo Físico
Acervo Físico
Produção Intelectual da USP
Produção USP
Search For:
Clear Search Box
Search in:
Busca Geral
Or hit Enter to replace search target
Or select another collection:
Search in:
Busca Geral
Busca Avançada
Busca por Índices
This feature requires javascript
This feature requires javascript
Thermothelomyces thermophilus as industrial cell factory for high titter of biomoleculaes production
Julia R. Ortega Gabriela Leila Berto; Fernando Segato
Anais do 32º Congresso Brasileiro de Microbiologia 2023 n. 1290-1, 2023
Foz do Iguaçú-PR SBM 2023
Acesso online
Exibir Online
Detalhes
Resenhas & Tags
Mais Opções
This feature requires javascript
Enviar para
Adicionar ao Meu Espaço
Remover do Meu Espaço
E-mail (máximo 30 registros por vez)
Imprimir
Link permanente
Referência
EasyBib
EndNote
RefWorks
del.icio.us
Exportar RIS
Exportar BibTeX
This feature requires javascript
Título:
Thermothelomyces thermophilus as industrial cell factory for high titter of biomoleculaes production
Autor:
Julia R. Ortega
Gabriela Leila Berto
;
Fernando Segato
Assuntos:
MICROBIOLOGIA
;
BIOTECNOLOGIA
;
Extracellular Protein Production
;
Fungal Cell Factories
;
Precision Fermentation
É parte de:
Anais do 32º Congresso Brasileiro de Microbiologia 2023 n. 1290-1, 2023
Notas:
Disponível em: https://sbmicrobiologia.org.br/32cbm-anais/resumos/R-1290-1.html. Acesso em: 30 nov. 2023.
Descrição:
Filamentous fungi naturally secrete a diverse array of proteins and enzymes to decompose various organic carbon sources (e.g., lignocellulosic biomass) into monomeric sugars (e.g.,glucose and xylose) for their metabolic processes. These fungi can serve as excellent industrial platforms for the production of bioproducts with biotechnological significance, owing to their ability to achieve high secretion titers of biomolecules, their easy industrial manipulation, and their capacity to perform various post-translational modifications, such as glycosylation and disulfide bond formation, unlike observed in other industrial cell factories, like bacteria and yeast. Among these, Thermothelomyces thermophilus emerges as a particularly promising industrial cell factory for biomolecules production, displaying morphological characteristics suitable for large-scale fermentable processes. To utilize T. thermophilus as a cell factory for protein production, we optimized the cultivation conditions and carbon sources in submerged fermentation. The submerged fermentations were conducted in 250 ml flasks, at controlled temperature and agitation, employing three different carbon sources (glucose, lactose, and sucrose) and two distinct media (Minimal and Mandels-Weber). The consumption of these carbon sources, pH variation, extracellular protein production, and fungi biomass were evaluated. The results allowed us to identify the optimal media, carbon source, and culture conditions for producing high levels of extracellular proteins from T. thermophilus. By defining cultivation parameters and the profile of carbon source consumption, we can improve T. thermophilus as an industrial cell factory through synthetic modifications aiming to increase extracellular protein production in submerged fermentation processes.
Editor:
Foz do Iguaçú-PR SBM
Data de criação/publicação:
2023
Formato:
n. 1290-1.
Idioma:
Inglês
Links
Este item no Dedalus
Acesso ao documento completo
This feature requires javascript
This feature requires javascript
Voltar para lista de resultados
This feature requires javascript
This feature requires javascript
Buscando em bases de dados remotas. Favor aguardar.
Buscando por
em
scope:(USP_VIDEOS),scope:("PRIMO"),scope:(USP_FISICO),scope:(USP_EREVISTAS),scope:(USP),scope:(USP_EBOOKS),scope:(USP_PRODUCAO),primo_central_multiple_fe
Mostrar o que foi encontrado até o momento
This feature requires javascript
This feature requires javascript