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New topical microemulsions of etofenamate as sufficient management of osteoarthritis

Üstündağ Okur, Neslihan; Onay, Ecehan; Kadıoğlu Yaman, Beril; Sipahi, Hande

Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)

Universidade de São Paulo. Faculdade de Ciências Farmacêuticas 2022-12-23

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  • Título:
    New topical microemulsions of etofenamate as sufficient management of osteoarthritis
  • Autor: Üstündağ Okur, Neslihan; Onay, Ecehan; Kadıoğlu Yaman, Beril; Sipahi, Hande
  • Assuntos: Etofenamate; Nonsteroidal Anti-Inflammatory Drug; Microemulsion; Ex Vivo; Cytotoxicity; Anti-Inflammatory Activity
  • É parte de: Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
  • Descrição: In this study, microemulsions containing etofenamate were prepared and evaluated as dermal delivery carriers. The developed microemulsions consist of oleic acid, Span 80, Tween 20, Cremophor EL, Transcutol and ethanol. The percentage of etofenamate loading in the microemulsions was 5% (w/w). The characterization of formulations included droplet size, zeta potential, pH, conductivity, PDI, refractive index and viscosity. Moreover, ex vivo penetration study was carried out using mice abdominal skin. The developed formulations were analyzed for their cytotoxicity via MTT assay and tested for their anti-inflammatory properties opposed to LPS-stimulated nitrite prοduction in RAW 264.7 cells. As ideal formulation, M2ETF, was chosen due to its greater permeation, lower penetration as well as higher anti-inflammatory activity compared to other microemulsions.
  • Títulos relacionados: https://www.revistas.usp.br/bjps/article/view/205308/188887
  • Editor: Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
  • Data de criação/publicação: 2022-12-23
  • Idioma: Inglês
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