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High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

Abeler-Dörner, Lucie ; Laing, Adam G ; Lorenc, Anna ; Ushakov, Dmitry S ; Clare, Simon ; Speak, Anneliese O ; Duque-Correa, Maria A ; White, Jacqueline K ; Ramirez-Solis, Ramiro ; Saran, Namita ; Bull, Katherine R ; Morón, Belén ; Iwasaki, Jua ; Barton, Philippa R ; Caetano, Susana ; Hng, Keng I ; Cambridge, Emma ; Forman, Simon ; Crockford, Tanya L ; Griffiths, Mark ; Kane, Leanne ; Harcourt, Katherine ; Brandt, Cordelia ; Notley, George ; Babalola, Kolawole O ; Warren, Jonathan ; Mason, Jeremy C ; Meeniga, Amrutha ; Karp, Natasha A ; Melvin, David ; Cawthorne, Eleanor ; Weinrick, Brian ; Rahim, Albina ; Drissler, Sibyl ; Meskas, Justin ; Yue, Alice ; Lux, Markus ; Song-Zhao, George X ; Chan, Anna ; Ballesteros Reviriego, Carmen ; Abeler, Johannes ; Wilson, Heather ; Przemska-Kosicka, Agnieszka ; Edmans, Matthew ; Strevens, Natasha ; Pasztorek, Markus ; Meehan, Terrence F ; Powrie, Fiona ; Brinkman, Ryan ; Dougan, Gordon ; Jacobs, Jr, William ; Lloyd, Clare M ; Cornall, Richard J ; Maloy, Kevin J ; Grencis, Richard K ; Griffiths, Gillian M ; Adams, David J ; Hayday, Adrian C

Nature immunology, 2020-01, Vol.21 (1), p.86-100 [Periódico revisado por pares]

United States: Nature Publishing Group

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Título:
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation
Autor: Abeler-Dörner, Lucie ; Laing, Adam G ; Lorenc, Anna ; Ushakov, Dmitry S ; Clare, Simon ; Speak, Anneliese O ; Duque-Correa, Maria A ; White, Jacqueline K ; Ramirez-Solis, Ramiro ; Saran, Namita ; Bull, Katherine R ; Morón, Belén ; Iwasaki, Jua ; Barton, Philippa R ; Caetano, Susana ; Hng, Keng I ; Cambridge, Emma ; Forman, Simon ; Crockford, Tanya L ; Griffiths, Mark ; Kane, Leanne ; Harcourt, Katherine ; Brandt, Cordelia ; Notley, George ; Babalola, Kolawole O ; Warren, Jonathan ; Mason, Jeremy C ; Meeniga, Amrutha ; Karp, Natasha A ; Melvin, David ; Cawthorne, Eleanor ; Weinrick, Brian ; Rahim, Albina ; Drissler, Sibyl ; Meskas, Justin ; Yue, Alice ; Lux, Markus ; Song-Zhao, George X ; Chan, Anna ; Ballesteros Reviriego, Carmen ; Abeler, Johannes ; Wilson, Heather ; Przemska-Kosicka, Agnieszka ; Edmans, Matthew ; Strevens, Natasha ; Pasztorek, Markus ; Meehan, Terrence F ; Powrie, Fiona ; Brinkman, Ryan ; Dougan, Gordon ; Jacobs, Jr, William ; Lloyd, Clare M ; Cornall, Richard J ; Maloy, Kevin J ; Grencis, Richard K ; Griffiths, Gillian M ; Adams, David J ; Hayday, Adrian C
Assuntos: Animals ; B cells ; Bioinformatics ; Biology ; Citrobacter - immunology ; Enterobacteriaceae Infections - immunology ; Enterobacteriaceae Infections - microbiology ; Female ; Genes ; Genetic screening ; Genetic Variation - genetics ; Genomes ; Genomics ; High-Throughput Screening Assays - methods ; Humans ; Immune response ; Immune system ; Immunology ; Immunophenotyping - methods ; Infections ; Laboratories ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Animal ; Phenotypic variations ; Phenotyping ; Salmonella ; Salmonella - immunology ; Salmonella Infections - immunology ; Salmonella Infections - microbiology ; Stem cells
É parte de: Nature immunology, 2020-01, Vol.21 (1), p.86-100
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: By developing a high-density murine immunophenotyping platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation (http://www.immunophenotype.org). Specifically, high-throughput phenotyping of 530 unique mouse gene knockouts identified 140 monogenic 'hits', of which most had no previous immunologic association. Furthermore, hits were collectively enriched in genes for which humans show poor tolerance to loss of function. The immunophenotyping platform also exposed dense correlation networks linking immune parameters with each other and with specific physiologic traits. Such linkages limit freedom of movement for individual immune parameters, thereby imposing genetically regulated 'immunologic structures', the integrity of which was associated with immunocompetence. Hence, we provide an expanded genetic resource and structural perspective for understanding and monitoring immune variation in health and disease.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

United States: Nature Publishing Group

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