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Effect of eight weeks of aerobic training and curcumin supplementation on PGC1-alpha gene expression and mitochondrial citrate synthase in Cardiomyocytes of male rats with myocardial infarction model

Alireza Nikoozadeh ; Roghayeh Pouzesh-Jadidi ; Alireza Nourazar ; Masoud Asgharpour-Arshad ; Jabar Bashiri

Fayz, 2022-10, Vol.26 (4), p.398-406 [Periódico revisado por pares]

Kashan University of Medical Sciences and Health Services

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  • Título:
    Effect of eight weeks of aerobic training and curcumin supplementation on PGC1-alpha gene expression and mitochondrial citrate synthase in Cardiomyocytes of male rats with myocardial infarction model
  • Autor: Alireza Nikoozadeh ; Roghayeh Pouzesh-Jadidi ; Alireza Nourazar ; Masoud Asgharpour-Arshad ; Jabar Bashiri
  • Assuntos: aerobic exercise ; citrate synthase ; curcumin ; myocardial infarction ; peroxisome proliferator activated receptor alpha ; pgc1-α
  • É parte de: Fayz, 2022-10, Vol.26 (4), p.398-406
  • Descrição: Background: Mitochondrial dysfunction is one of the possible mechanisms for the progression of heart disease. This study aimed to effect of eight weeks of aerobic training and curcumin supplementation on PGC1- α gene expression and cardiomyocyte mitochondrial citrate synthase in Cardiomyocytes of male rats with myocardial infarction model. Materials and Methods: 40 male rats were randomly divided into 5 groups: healthy control, heart myocardial infarction control, aerobic exercise, supplement and exercise + supplement. The training and training+supplement groups were influenced by training on the intelligent electronic animal treadmill for 8 weeks, 5 days a week. At this time, the myocardial infarction control and supplement groups had no exercise program. First, healthy controls were killed. Expression of PGC1-α gene and mitochondrial citrate synthase using real-time PCR method, the obtained data were analyzed using Shapiro-Wilk test, two-way and one-way analysis of variance and Tukey's post hoc test. Result: Results showed that the expression of PGC1-α and citrate synthase of cardiomyocytes in the groups trained with and without curcumin consumption is significantly higher than the supplemented and myocardial infarction control groups (P=0.001). No significant difference was observed between the two groups of exercise and exercise + supplement. The expression of both genes in the myocardial infarction control group was lower than that of healthy controls (P≤0.05). Conclusion: Eight weeks of aerobic exercise alone and in combination with curcumin increased the expression of PGC1-α gene and citrate synthase. The combined effect of exercise and curcumin were nonsignificantly greater.
  • Editor: Kashan University of Medical Sciences and Health Services
  • Idioma: Persa
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