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Dose- and type-dependent effects of long-chain fatty acids on adipogenesis and lipogenesis of bovine adipocytes

Yanting, Chen ; Yang, Q.Y. ; Ma, G.L. ; Du, M. ; Harrison, J.H. ; Block, E.

Journal of dairy science, 2018-02, Vol.101 (2), p.1601-1615 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Dose- and type-dependent effects of long-chain fatty acids on adipogenesis and lipogenesis of bovine adipocytes
  • Autor: Yanting, Chen ; Yang, Q.Y. ; Ma, G.L. ; Du, M. ; Harrison, J.H. ; Block, E.
  • Assuntos: Adipocytes - drug effects ; Adipocytes - physiology ; adipogenesis ; Animals ; Cattle - physiology ; Cell Differentiation - drug effects ; Cells, Cultured ; dairy cow ; Dose-Response Relationship, Drug ; fatty acid ; Fatty Acids - classification ; Fatty Acids - pharmacology ; Female ; Lipid Metabolism - drug effects ; lipogenesis ; Lipogenesis - drug effects ; Milk - metabolism ; stromal vascular cell
  • É parte de: Journal of dairy science, 2018-02, Vol.101 (2), p.1601-1615
  • Descrição: Differentiation and lipid metabolism of adipocytes have a great influence on milk performance, health, and feed efficiency of dairy cows. The effects of dietary long-chain fatty acids (FA) on adipogenesis and lipogenesis of dairy cows are often confounded by other nutritional and physiological factors in vivo. Therefore, this study used an in vitro approach to study the effect of dose and type of long-chain FA on adipogenesis and lipogenesis of bovine adipocytes. Stromal vascular cells were isolated from adipose tissue of dairy cows and induced into mature adipocytes in the presence of various long-chain FA including myristic, palmitic, stearic, oleic, or linoleic acid. When concentrations of myristic, palmitic, and oleic acids in adipogenic mediums were 150 and 200 μM, the induced mature adipocytes had greater lipid content compared with other concentrations of FA. In addition, mature adipocytes induced at 100 μM stearic acid and 300 μM linoleic acid had the greatest content of lipid than at other concentrations. High concentrations of saturated FA were more toxic for cells than the same concentration of unsaturated FA during the induction. When commitment stage was solely treated with FA, the number of differentiated mature adipocytes was greater for oleic and linoleic acids than other FA. When the maturation stage was treated with FA, the number of mature adipocytes was not affected, but the lipid content in adipocytes was affected and ranked oleic > linoleic > myristic > stearic > palmitic. In summary, this study showed that adipogenesis and lipogenesis of bovine adipocytes were differentially affected by long-chain FA, with unsaturated FA more effective than saturated FA.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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