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Elevated Incidence of Posttransplant Erythrocytosis After Simultaneous Pancreas Kidney Transplantation

Guerra, G. ; Indahyung, R. ; Bucci, C. M. ; Schold, J. D. ; Magliocca, J. F. ; Meier‐Kriesche, H.‐U.

American journal of transplantation, 2010-04, Vol.10 (4), p.938-942 [Periódico revisado por pares]

Malden, USA: Blackwell Publishing Inc

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Título:
Elevated Incidence of Posttransplant Erythrocytosis After Simultaneous Pancreas Kidney Transplantation
Autor: Guerra, G. ; Indahyung, R. ; Bucci, C. M. ; Schold, J. D. ; Magliocca, J. F. ; Meier‐Kriesche, H.‐U.
Assuntos: Adult ; Biological and medical sciences ; Diabetes ; Diabetes mellitus ; Diseases of red blood cells ; Epidemiology ; Female ; General aspects ; Hematocrit ; Hematologic and hematopoietic diseases ; Humans ; Incidence ; Kidney transplantation ; Kidney Transplantation - adverse effects ; Kidney transplants ; Male ; Medical sciences ; Pancreas transplantation ; Pancreas Transplantation - adverse effects ; Polycythemia ; Polycythemia - etiology ; Polycythemias ; post transplant erythrocytosis ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Thrombosis
É parte de: American journal of transplantation, 2010-04, Vol.10 (4), p.938-942
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Posttransplant erythrocytosis (PTE) poses a potential risk of thrombosis in kidney transplantation. Clinical observation of our systemically drained simultaneous kidney pancreas transplant (S‐SPK) patients showed a higher incidence of PTE and need for phlebotomies. To evaluate the incidence of PTE we analyzed hematocrit (Hct) levels and frequency of phlebotomies in 94 SPK as compared to 174 living donor (LD) recipients and 53 type‐I diabetic with kidney transplant only. For study purposes we defined PTE as Hct >50% or the necessity for phlebotomies. Kaplan–Meier plots and Cox proportional hazard models were used to examine the association between the transplant type and PTE. We found an increased incidence of PTE in SPK compared to LD (p < 0.001). In the multivariate model, SPK had a 5‐fold risk for the development of PTE (AHR 5.3, 95% CI 1.8, 15.9). The incidence of therapeutic phlebotomy was 13% among SPK patients and 4% in LD kidney recipients; 19 patients altogether. A total of 64 units were phlebotomized (48‐SPK and 16‐LD). Type I diabetic patients with a kidney transplant showed a 0% incidence of PTE. We observed a greater incidence of PTE and phlebotomies in S‐SPK compared to LD with kidney only transplant recipients. Combined Kidney Pancreas transplantation is associated with an increased incidence of polycythemia.
Editor: Malden, USA: Blackwell Publishing Inc
Idioma: Inglês

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Elevated Incidence of Posttransplant Erythrocytosis After Simultaneous Pancreas Kidney Transplantation

Guerra, G. ; Indahyung, R. ; Bucci, C. M. ; Schold, J. D. ; Magliocca, J. F. ; Meier‐Kriesche, H.‐U.

Malden, USA: Blackwell Publishing Inc

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