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Doxorubicin cardiotoxicity and Camellia sinensis cardioprotection determined by speckle-tracking echocardiography

Souza Oliveira Barreto, Maira; Lott Carvalho, Juliana; Barrouin Melo, Marcos; Ribeiro Machado Michel, Ana Fl��Via; Guimar��Es Ferreira, Marina; Aparecida L��Zaro Muzzi, Ruthn��A; Miranda De Goes, Alfredo; Martins Melo , Marilia

Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); 14

Universidade de S��o Paulo. Faculdade de Ci��ncias Farmac��uticas 2023-08-28

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  • Título:
    Doxorubicin cardiotoxicity and Camellia sinensis cardioprotection determined by speckle-tracking echocardiography
  • Autor: Souza Oliveira Barreto, Maira; Lott Carvalho, Juliana; Barrouin Melo, Marcos; Ribeiro Machado Michel, Ana Fl��Via; Guimar��Es Ferreira, Marina; Aparecida L��Zaro Muzzi, Ruthn��A; Miranda De Goes, Alfredo; Martins Melo , Marilia
  • Assuntos: Flavonoids; Green Tea; Heart Injury; Radial Strain; Longitudinal Strain
  • É parte de: Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); 14
  • Descrição: Doxorubicin (Dox) is a medication used in the treatment of cancerous tumors and hematologic malignancies with potentially serious side effects, including the risk of cardiotoxicity. Flavonoids are plant metabolites with antioxidant properties and can be extracted from Camellia sinensis (CS). The aim of this study is to evaluate the possible cardioprotective effect of CS against injuries induced by Dox in rats. A total of 32 animals were distributed into four groups: (1) control - intraperitoneal injection (I.P.) of 0.5 mL saline weekly and 1.0 mL water by gavage daily; (2) CS - 0.5 mL saline I.P. weekly and 200 mg/kg CS by gavage daily; (3) Dox - 5.0 mg/kg Dox I.P. weekly and 1.0 mL water by gavage daily; and (4) Dox+CS -5.0 mg/kg Dox I.P. weekly and 200 mg/kg CS by gavage daily. Clinical examinations, blood profiles, electrocardiograms, echocardiograms, and histological analyses of hearts were performed over 25 days. The animals in the Dox group showed changes in body weight and in erythrogram, leukogram, electrocardiography, and echocardiography readings. However, animals from the dox+CS group had significantly less change in body weight, improved cardiac function, and showed more preserved cardiac tissue. This study demonstrated that CS prevents dox-induced cardiotoxicity, despite enhancing the cytotoxic effect on blood cells.
  • DOI: 10.1590/
  • Editor: Universidade de S��o Paulo. Faculdade de Ci��ncias Farmac��uticas
  • Data de criação/publicação: 2023-08-28
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