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Alterations in oxidative stress parameters and its associated correlation with clinical disease on experimental Cryptosporidium parvum infection in Swiss albino mice

Bhagat, Meenakshi ; Sood, Shilpa ; Yadav, Anish ; Verma, Pawan ; Manzoor, Nasir ; Chakraborty, D. ; Katoch, Rajesh ; Sangha, Navrose

Journal of parasitic diseases, 2017-09, Vol.41 (3), p.707-712 [Periódico revisado por pares]

New Delhi: Springer India

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Título:
Alterations in oxidative stress parameters and its associated correlation with clinical disease on experimental Cryptosporidium parvum infection in Swiss albino mice
Autor: Bhagat, Meenakshi ; Sood, Shilpa ; Yadav, Anish ; Verma, Pawan ; Manzoor, Nasir ; Chakraborty, D. ; Katoch, Rajesh ; Sangha, Navrose
Assuntos: Albinism ; Cryptosporidium ; Dexamethasone ; Diarrhea ; Drinking water ; Experimental infection ; Health Promotion and Disease Prevention ; Infections ; Infectious Diseases ; Intestine ; Liver ; Medicine ; Medicine & Public Health ; Oocysts ; Original ; Original Article ; Oxidative stress ; Protozoa
É parte de: Journal of parasitic diseases, 2017-09, Vol.41 (3), p.707-712
Descrição: The present study was conducted to evaluate the changes in oxidative stress parameters on experimental infection with Cryptosporidium parvum in Swiss albino mice. The mice were divided into four groups viz., group I–IV, each group comprising of 15 mice. Group I mice served as healthy control. In Group II mice, C. parvum oocysts @ 10 4 /os were administered, mice of group III were given dexamethasone @ 30 µg/ml in drinking water whereas group IV mice were given dexamethasone @ 30 µg/ml along with C. parvum oocysts @ 10 4 /os. Significant changes were seen in oxidative stress parameters which included significant increase in LPO and decrease in levels of SOD, CAT and GSH in liver and intestine in group IV mice at 10th DPI when compared to others indicating an important role played by free radical induced oxidative stress in the development of C. parvum infection in mice which was clinically characterized by loss of body condition, profuse bloody diarrhoea and peak oocyst shedding intensity occurring at 10th DPI.
Editor: New Delhi: Springer India
Idioma: Inglês

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Alterations in oxidative stress parameters and its associated correlation with clinical disease on experimental Cryptosporidium parvum infection in Swiss albino mice

Bhagat, Meenakshi ; Sood, Shilpa ; Yadav, Anish ; Verma, Pawan ; Manzoor, Nasir ; Chakraborty, D. ; Katoch, Rajesh ; Sangha, Navrose

New Delhi: Springer India

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