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Microbial 2-Cys Peroxiredoxins: Insights into Their Complex Physiological Roles

Toledano, Michel B ; Huang, Bo

Molecules and Cells, 2016, 39(1), , pp.31-39 [Periódico revisado por pares]

United States: Korean Society for Molecular and Cellular Biology

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Título:
Microbial 2-Cys Peroxiredoxins: Insights into Their Complex Physiological Roles
Autor: Toledano, Michel B ; Huang, Bo
Assuntos: Bacteria - enzymology ; Bacteria - growth & development ; Bacterial Proteins - physiology ; Catalysis ; Free Radical Scavengers - metabolism ; Fungal Proteins - physiology ; Hydrogen Peroxide - metabolism ; Minireview ; Molecular Chaperones - metabolism ; Mutation ; Peroxiredoxins - physiology ; Signal Transduction ; Yeasts - enzymology ; Yeasts - growth & development ; 생물학
É parte de: Molecules and Cells, 2016, 39(1), , pp.31-39
Notas: KISTI1.1003/JNL.JAKO201606050646445
G704-000079.2016.39.1.001
Descrição: The peroxiredoxins (Prxs) constitute a very large and highly conserved family of thiol-based peroxidases that has been discovered only very recently. We consider here these enzymes through the angle of their discovery, and of some features of their molecular and physiological functions, focusing on complex phenotypes of the gene mutations of the 2-Cys Prxs subtype in yeast. As scavengers of the low levels of H2O2 and as H2O2 receptors and transducers, 2-Cys Prxs have been highly instrumental to understand the biological impact of H2O2, and in particular its signaling function. 2-Cys Prxs can also become potent chaperone holdases, and unveiling the in vivo relevance of this function, which is still not established, should further increase our knowledge of the biological impact and toxicity of H2O2. The diverse molecular functions of 2-Cys Prx explain the often-hard task of relating them to peroxiredoxin genes phenotypes, which underscores the pleiotropic physiological role of these enzymes and complex biologic impact of H2O2.
Editor: United States: Korean Society for Molecular and Cellular Biology
Idioma: Inglês;Coreano

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Microbial 2-Cys Peroxiredoxins: Insights into Their Complex Physiological Roles

Toledano, Michel B ; Huang, Bo

United States: Korean Society for Molecular and Cellular Biology

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