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Adverse events in a cohort of HIV infected pregnant and non-pregnant women treated with nevirapine versus non-nevirapine antiretroviral medication

Aaron, Erika ; Kempf, Mirjam-Colette ; Criniti, Shannon ; Tedaldi, Ellen ; Gracely, Ed ; Warriner, Amy ; Kumar, Ritu ; Bachmann, Laura H Myer, Landon

PloS one, 2010-09, Vol.5 (9), p.e12617 [Periódico revisado por pares]

United States: Public Library of Science

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Adverse events in a cohort of HIV infected pregnant and non-pregnant women treated with nevirapine versus non-nevirapine antiretroviral medication
Autor: Aaron, Erika ; Kempf, Mirjam-Colette ; Criniti, Shannon ; Tedaldi, Ellen ; Gracely, Ed ; Warriner, Amy ; Kumar, Ritu ; Bachmann, Laura H
Myer, Landon
Assuntos: Acquired immune deficiency syndrome ; Adult ; AIDS ; Analysis ; Anti-HIV Agents - adverse effects ; Anti-HIV Agents - therapeutic use ; Antiretroviral agents ; Antiretroviral drugs ; Antiviral agents ; CD4 antigen ; CD4 Lymphocyte Count ; Clinical medicine ; Cohort Studies ; Complications and side effects ; Drug therapy ; Drugs ; Enzymes ; Exanthema ; Female ; Follow-Up Studies ; Hepatitis ; Hepatitis C virus ; Highly active antiretroviral therapy ; HIV ; HIV (Viruses) ; HIV Infections - drug therapy ; HIV Infections - immunology ; HIV patients ; Human immunodeficiency virus ; Humans ; Infections ; Infectious diseases ; Infectious Diseases/HIV Infection and AIDS ; Laboratories ; Liver ; Middle Aged ; Nevirapine ; Nevirapine - adverse effects ; Nevirapine - therapeutic use ; Obstetrics/Pregnancy ; Pharmacology/Adverse Reactions ; Pregnancy ; Pregnancy Complications, Infectious - drug therapy ; Pregnancy Complications, Infectious - immunology ; Pregnancy Complications, Infectious - virology ; Pregnant women ; Preventive medicine ; Regression analysis ; Retrospective Studies ; Risk factors ; Toxicity ; Womens health ; Young Adult
É parte de: PloS one, 2010-09, Vol.5 (9), p.e12617
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Conceived and designed the experiments: EA. Performed the experiments: EA MCK SC ET AHW RAK LHB. Analyzed the data: EA MCK SC ET EJG LHB. Contributed reagents/materials/analysis tools: EA. Wrote the paper: EA MCK SC ET AHW RAK LHB.
Descrição: Predictors of adverse events (AE) associated with nevirapine use are needed to better understand reports of severe rash or liver enzyme elevation (LEE) in HIV+ women. AE rates following ART initiation were retrospectively assessed in a multi-site cohort of 612 women. Predictors of onset of rash or LEE were determined using univariate and multivariate analyses. Of 612 subjects, 152 (24.8%) initiated NVP-based regimens with 86 (56.6%) pregnant; 460 (75.2%) initiated non-NVP regimens with 67 (14.6%) pregnant. LEE: No significant difference was found between regimens in the development of new grade ≥2 LEE (p = 0.885). Multivariate logistic regression demonstrated an increased likelihood of LEE with HCV co-infection (OR 2.502, 95% CI: 1.04 to 6, p = 0.040); pregnancy, NVP-based regimen, and baseline CD4 >250 cells/mm(3) were not associated with this toxicity. RASH: NVP initiation was associated with rash after controlling for CD4 and pregnancy (OR 2.78; 95%CI: 1.14-6.76), as was baseline CD4 >250 cells/mm(3) when controlling for pregnancy and type of regimen (OR 2.68; 95% CI: 1.19-6.02 p = 0.017). CD4 at initiation of therapy was a predictor of rash but not LEE with NVP use in HIV+ women. Pregnancy was not an independent risk factor for the development of AEs assessed. The findings from this study have significant implications for women of child-bearing age initiating NVP-based ART particularly in resource limited settings. This study sheds more confidence on the lack of LEE risk and the need to monitor rash with the use of this medication.
Editor: United States: Public Library of Science
Idioma: Inglês

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Adverse events in a cohort of HIV infected pregnant and non-pregnant women treated with nevirapine versus non-nevirapine antiretroviral medication

Aaron, Erika ; Kempf, Mirjam-Colette ; Criniti, Shannon ; Tedaldi, Ellen ; Gracely, Ed ; Warriner, Amy ; Kumar, Ritu ; Bachmann, Laura H Myer, Landon

United States: Public Library of Science

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