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A risk-adapted approach to acute GVHD treatment: are we there yet?

Holtan, S G ; MacMillan, M L

Bone marrow transplantation (Basingstoke), 2016-02, Vol.51 (2), p.172-175 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
A risk-adapted approach to acute GVHD treatment: are we there yet?
Autor: Holtan, S G ; MacMillan, M L
Assuntos: Acute Disease ; Allografts ; Bone marrow ; Care and treatment ; Clinical trials ; Complications and side effects ; Diagnosis ; Graft vs Host Disease - prevention & control ; Graft vs. host disease ; Graft-versus-host reaction ; Hematopoietic Stem Cell Transplantation ; Humans ; Impact damage ; Models, Biological ; Patient outcomes ; Patients ; Predictive Value of Tests ; Risk ; Risk Assessment - methods ; Risk Factors ; Stem cell transplantation ; Transplantation
É parte de: Bone marrow transplantation (Basingstoke), 2016-02, Vol.51 (2), p.172-175
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
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Descrição: Acute GVHD (aGVHD) is an immunologic complication of allogeneic hematopoietic cell transplantation (HCT) that can range from mild to life-threatening. Models to predict patients at risk of poor outcomes have been developed using both clinical and laboratory data, and the time to test these models in clinical trials has arrived. However, each modeling method has its potential advantages and limitations. In this mini-review, we summarize recent refinements to these models. We also suggest avenues for improving risk stratification through further studies of a patient's healing capacity and predisposition to endothelial damage, two factors that impact aGVHD outcomes but are absent from the current risk stratification models.
Editor: England: Nature Publishing Group
Idioma: Inglês

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A risk-adapted approach to acute GVHD treatment: are we there yet?

Holtan, S G ; MacMillan, M L

England: Nature Publishing Group

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